Evidence map›Paper›PMID 20425512›Full record

ArticleCurrent allergy and asthma reports2010

Anaphylaxis and mast cell disease: what is the risk?

Cem Akin

Abstract read
PubMed Publisher
In one paragraph

Article in Current allergy and asthma reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Systemic Mastocytosis: State of the Art.Current hematologic malignancy reports · 2024
    Review
  3. Review
  4. Article
  5. Microarray-Based Detection of Allergen-Reactive IgE in Patients with Mastocytosis.The journal of allergy and clinical immunology. In practice · 2020
    Article
  6. Review
  7. The Role of KIT Mutations in Anaphylaxis.Current allergy and asthma reports · 2019
    Review
  8. Review
  9. A novel combination of an IgE mediated adult onset food allergy and a suspected mast cell activation syndrome presenting as anaphylaxis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016
    Article
  10. Risk factors and management of severe life-threatening anaphylaxis in patients with clonal mast cell disorders.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Cem AkinHarvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Immunology, and Allergy, Smith Building, Room 626B, Boston, MA 02445, USA. cakin@rics.bwh.harvard.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mastocytosis is a proliferative disorder of the hematopoietic mast cell progenitor that results from expansion of a clone carrying the D816V c-kit mutation. Based on the dramatic increase in incidence of anaphylaxis in patients with mastocytosis, recent studies analyzed the presence of clonal mast cell markers, including D816V c-kit mutation, in patients with recurrent IgE- and non-IgE-mediated anaphylaxis. These studies demonstrated the presence of an aberrant mast cell clone in a significant proportion of patients with unexplained anaphylaxis, or anaphylaxis due to hymenoptera venom. Clonal mast cell disease should be suspected in particular in patients presenting with profound cardiovascular manifestations such as hypotension and syncope in the absence of urticaria.

Indexed as

Insect Bites and StingsMastocytosisAnaphylaxisAnimalsArthropod VenomsHumansHymenopteraHypotensionMast CellsMutationProto-Oncogene Proteins c-kitRiskSyncopeUrticariaArthropod VenomsProto-Oncogene Proteins c-kit

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.