ReviewCurrent allergy and asthma reports2010
Chronic helminth infections protect against allergic diseases by active regulatory processes.
Review in Current allergy and asthma reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Pooled it
- Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses: a systematic review.Parasites & vectors · 2018Pooled it
- Effects of treating helminths during pregnancy and early childhood on risk of allergy-related outcomes: Follow-up of a randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2017Trial
- Trial
- Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?Parasitology · 2011Trial
- Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics.Antonie van Leeuwenhoek · 2026Review
- Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells inPathogens (Basel, Switzerland) · 2026Article
- Determinants of clinical severity in children with sickle cell disease and confirmed asthma.PloS one · 2026Observational
- Evaluation of Total Serum IgE Level and Associated Factors in Asthmatic Patients at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
- CouldFrontiers in allergy · 2026Article
- Levels of Exhaled Fraction of Nitric Oxide (FeNO) and Type 2 Biomarkers in Individuals Naturally Exposed to Helminth Parasites in a Tropical Region.International journal of molecular sciences · 2025Article
- Coevolutionary interplay: Helminths-trained immunity and its impact on the rise of inflammatory diseases.eLife · 2025Review
- Helminth Seropositivity Inversely Correlated with Th1 and Th17 Cytokines and Severe COVID-19.Vaccines · 2025Article
- Evaluating the Toxocara cati extract as a therapeutic agent for allergic airway inflammation.Immunity, inflammation and disease · 2024Article
- Type I Cystatin Derived fromMicroorganisms · 2024Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Severely Asthmatic Horses Residing in a Mediterranean Climate Shed a Significantly Lower Number of Parasite Eggs Compared to Healthy Farm Mates.Animals : an open access journal from MDPI · 2023Article
- Ascaridia galli infection in chicken: Pathobiology and immunological orchestra.Immunity, inflammation and disease · 2023Review
- The Potential Nexus between Helminths and SARS-CoV-2 Infection: A Literature Review.Journal of immunology research · 2023Review
- Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization.Parasites & vectors · 2022Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developed countries are suffering from an epidemic rise in immunologic disorders, such as allergy-related diseases and certain autoimmunities. Several studies have demonstrated a negative association between helminth infections and inflammatory diseases (eg, allergy), providing a strong case for the involvement of helminth infections in this respect. However, some studies point in the opposite direction. The discrepancy may be explained by differences in frequency, dose, time, and type of helminth. In this review, new studies are discussed that may support the concept that chronic helminth infections in particular-but not acute infections-are associated with the expression of regulatory networks necessary for downmodulating allergic immune responses to harmless antigens. Furthermore, different components of regulatory networks are highlighted, such as the role of regulatory T and B cells, modulation of dendritic cells, early innate signals from structural cells (eg, epithelial cells), and their individual contributions to protection against allergic diseases. It is of great interest to define and characterize specific helminth molecules that have profound immunomodulatory capacities as targets for therapeutic application in the treatment or prophylaxis of allergic manifestations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.