Evidence map›Paper›PMID 20425452›Full record

ReviewCurrent hematologic malignancy reports2008

The role of timed sequential chemotherapy in adult acute myelogenous leukemia.

Xavier Thomas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hematologic malignancy reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Xavier ThomasService d'Hématologie, Hôpital Edouard Herriot, Lyon Cedex 03, France. xavier.thomas@chu-lyon.fr
Hôpital Edouard Herriot · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consecutive trials of timed sequential chemotherapy (TSC) have been conducted in adults with acute myelogenous leukemia. The rationale for TSC was based on the observation that leukemic cells can be recruited synchronously into the cell cycle after initial intensive therapy, at which time they may become more susceptible to killing by chemotherapeutic agents. Achieving complete remission is essential for prolonged disease-free survival and may affect long-term outcome. TSC has led to higher rates of complete remission and has improved long-term outcomes. This article reviews the results of important trials in which TSC was used as an induction regimen in de novo, relapsed, or refractory acute myelogenous leukemia or as postremission therapy.

Indexed as

AdultAntineoplastic AgentsCell CycleClinical Trials as TopicDrug Administration ScheduleHumansLeukemia, Myeloid, AcuteAntineoplastic Agents

Identifiers

PMID20425452
OpenAlexW1972300877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.