ReviewCurrent psychiatry reports2010
Sensitivity to antipsychotic drugs in older adults.
Review in Current psychiatry reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Predictors and Moderators of Hospitalisation and Mortality in People with Dementia Using Antipsychotics: Systematic Review.Drugs & aging · 2025Pooled it
- Opti-Med: the effectiveness of optimised clinical medication reviews in older people with 'geriatric giants' in general practice; study protocol of a cluster randomised controlled trial.BMC geriatrics · 2014Trial
- Antipsychotic load during olanzapine mono- versus polytherapy and in relation to age.European journal of clinical pharmacology · 2025Article
- The Effect of Age on Antipsychotic Serum Concentration in Males and Females: A Study Based on Therapeutic Drug Monitoring Data From 19,926 Patients.Therapeutic drug monitoring · 2025Article
- Age and sex differences in outpatient antipsychotic prescriptions for schizophrenia: a claims data study.European archives of psychiatry and clinical neuroscience · 2025Article
- Potentially Inappropriate Medication Use in Older Adults with Alzheimer's Disease and Related Dementias Living in the Community: A Cross-Sectional Analysis.Drugs - real world outcomes · 2021Article
- The Interplay between Anticholinergic Burden and Anemia in Relation to 1-Year Mortality among Older Patients Discharged from Acute Care Hospitals.Journal of clinical medicine · 2021Article
- Potentially inappropriate medication in older psychiatric patients.European journal of clinical pharmacology · 2021Article
- Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Changes in medicine prescription following a medication review in older high-risk patients with polypharmacy.International journal of clinical pharmacy · 2018Article
- Epigenetic Alterations Impact on Antipsychotic Treatment in Elderly Patients.Current treatment options in psychiatry · 2018Article
- Antipsychotic Drug Dispensations in Older Adults, Including Continuation After a Fall-Related Hospitalization: Identifying Adherence to Screening Tool of Older Persons' Potentially Inappropriate Prescriptions Criteria Using the Nova Scotia Seniors' Pharmacare Program and Canadian Institute for Health's Discharge Databases.Current therapeutic research, clinical and experimental · 2018Article
- A population approach to characterise amisulpride pharmacokinetics in older people and Alzheimer's disease.Psychopharmacology · 2016Article
- Inflammation and psychotropic drugs: the relationship between C-reactive protein and antipsychotic drug levels.Psychopharmacology · 2016Article
- Side effects related to potentially inappropriate medications in elderly psychiatric patients under everyday pharmacotherapy.European journal of clinical pharmacology · 2015Article
- The effects of aging on insight into illness in schizophrenia: a review.International journal of geriatric psychiatry · 2014Review
- Behavioral disturbance in dementia.Current psychiatry reports · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antipsychotic medications are widely used to manage psychotic and behavioral disorders in older adults, including primary psychotic disorders such as schizophrenia, and psychosis and behavioral disturbances associated with dementia. These two broad diagnostic indications are associated with contrasting recommended treatment durations, with the former requiring indefinite treatment across the life span. Antipsychotic drug dosing for schizophrenia is based primarily on studies of younger patients and thus may not apply to older adults. It is critically important to address the effects of aging on antipsychotic dosing given the recent emergence of data that suggest a critical role for age-related sensitivity to these drugs. Antipsychotic drugs are not only associated with somatic and neurological adverse effects but also increased all-cause mortality and sudden cardiac death in this vulnerable population. This review focuses on the sensitivity of older adults to adverse effects from antipsychotic medications and the current pharmacokinetic and pharmacodynamic explanatory models of susceptibility. Implications of recent research findings for individualized pharmacotherapy are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.