Evidence map›Paper›PMID 20425261›Full record

ReviewCurrent atherosclerosis reports2010

Insights into atherosclerosis using nanotechnology.

Ashwath Jayagopal, Macrae F Linton, Sergio Fazio, Frederick R Haselton

Abstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
  6. Detection and treatment of atherosclerosis using nanoparticles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017
    Review
  7. Review
  8. Article
  9. Review
  10. Nanoengineering of therapeutics for retinal vascular disease.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2015
    Review
  11. Molecular imaging of retinal disease.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2013
    Review
  12. Inflammation in atherosclerosis: a cause or a result of vascular disorders?Journal of cellular and molecular medicine · 2012
    Review
  13. New technologies personalize diagnostics and therapeutics.Current atherosclerosis reports · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashwath JayagopalDepartment of Chemistry, Vanderbilt University, VU Station B Box 351822, Nashville, TN 37232, USA. ash.jayagopal@vanderbilt.edu
Macrae F Linton
Sergio Fazio
Frederick R Haselton

Funding

Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Multi-spectral quantum dot-based retinal imaging of molecular expression in vivoR21EY017522 · NEI · VANDERBILT UNIVERSITY · PI HASELTON, FREDERICK R · 2007 to 2009
$572k
Retinal Imaging of Prognostic Indicators of AtherosclerosisR21HL095119 · NHLBI · VANDERBILT UNIVERSITY · PI HASELTON, FREDERICK R · 2009 to 2010
$422k
NEI NIH HHS P30 EY008126NEI NIH HHS P30-EY008126NEI NIH HHS R21 EY017522NEI NIH HHS R21EY017522NHLBI NIH HHS R21 HL095119NHLBI NIH HHS R21HL095119NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U24DK059637
6 · The paper itself

Abstract

A developing forefront in vascular disease research is the application of nanotechnology, the engineering of devices at the molecular scale, for diagnostic and therapeutic applications in atherosclerosis. Promising research in this field over the past decade has resulted in the preclinical validation of nanoscale devices that target cellular and molecular components of the atherosclerotic plaque, including one of its prominent cell types, the macrophage. Nanoscale contrast agents targeting constituents of plaque biology have been adapted for application in multiple imaging modalities, leading toward more detailed diagnostic readouts, whereas nanoscale drug delivery devices can be tailored for site-specific therapeutic activity. This review highlights recent progress in utilizing nanotechnology for the clinical management of atherosclerosis, drawing upon recent preclinical studies relevant to diagnosis and treatment of the plaque and promising future applications.

Indexed as

AtherosclerosisAnimalsBiomedical ResearchDiagnostic ImagingEndothelium, VascularHumansMacrophagesNanoparticlesNanotechnologyReproducibility of Results

Identifiers

PMID20425261
PMCPMC2863145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.