ReviewCurrent neurology and neuroscience reports2010
Nocturnal leg cramps.
Review in Current neurology and neuroscience reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Criteria in diagnosing nocturnal leg cramps: a systematic review.BMC family practice · 2017Pooled it
- Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial.BMC complementary medicine and therapies · 2022Trial
- A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps.Nutrition journal · 2021Trial
- Muscle Cramps Do Not Improve With Correction of Vitamin D Insufficiency.WMJ : official publication of the State Medical Society of Wisconsin · 2017Trial
- Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial.JAMA internal medicine · 2017Trial
- Effects of Neuromuscular Electrical Stimulation on Cramp Threshold Frequency and Pain in Adults with Nocturnal Leg Cramps: An EMG-Based Assessment: Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2026Article
- Efficacy and Tolerability of Pridinol Mesylate Versus Quinine Sulfate in the Treatment of Nocturnal Leg Cramps: A Propensity Score-Matched Real-World Analysis of Depersonalized 4-Week Data from the German Pain e-Registry (PRISCILA Study).Journal of clinical medicine · 2026Article
- Fire Needle Therapy for Nocturnal Leg Cramps in Older Adults: A Randomized Sham-Controlled Pilot Trial Protocol.Journal of pain research · 2025Article
- Prevalence and Predictors of Leg Cramps in the Third Trimester of Pregnancy: A Cross-Sectional Study.International journal of women's health · 2024Article
- Sleep related movement disorders in the elderly: a review of recent literature.Frontiers in sleep · 2024Review
- Effect of vitamin K2 in the treatment of nocturnal leg cramps in the older population: Study protocol of a randomized, double-blind, controlled trial.Frontiers in nutrition · 2023Article
- Nocturnal Leg Cramps and Lumbar Spinal Stenosis: A Cross-Sectional Study in the Community.International journal of general medicine · 2022Article
- Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma.Targeted oncology · 2019Review
- Association Between Alcohol Consumption and Nocturnal Leg Cramps in Patients Over 60 Years Old: A Case-Control Study.Annals of family medicine · 2018Article
- Prevalence of cramps in patients over the age of 60 in primary care : a cross sectional study.BMC family practice · 2016Observational
- Nocturnal Arousal in a 68-Year-Old Woman.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- Incidence of nocturnal leg cramps in patients with lumbar spinal stenosis before and after conservative and surgical treatment.Yonsei medical journal · 2014Article
- Classification of sleep disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nocturnal leg cramps are a frequent cause of sleep disturbance among the general population, especially among the elderly. These painful episodes can delay sleep onset and awaken the patient from sleep, as well as delay subsequent return to sleep. Different mechanisms have been proposed to explain this phenomenon. Although most cases of leg cramps are idiopathic, multiple secondary causes of sleep-related leg cramps have been identified as well. In this article, we review the epidemiology, pathophysiology, and risk factors and discuss the salient features of the diagnosis and workup. Finally, we review the wide array of behavioral and pharmacologic treatments that have been studied for nocturnal leg cramps.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.