ArticleJournal of assisted reproduction and genetics2010
Extended in vitro maturation of immature oocytes from stimulated cycles: an analysis of fertilization potential, embryo development, and reproductive outcomes.
Article in Journal of assisted reproduction and genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- The effect of short-term exposure of cumulus-oocyte complexes to in vitro maturation medium on yield of mature oocytes and usable embryos in stimulated cycles.Journal of assisted reproduction and genetics · 2018Trial
- Advances, Mechanisms, and Clinical Perspectives for the In Vitro Maturation of Human Oocytes.International journal of molecular sciences · 2025Review
- Rescue in vitro maturation of germinal vesicle oocytes after ovarian stimulation: the importance of the culture media.Human reproduction (Oxford, England) · 2025Article
- Human Umbilical Cord Mesenchymal Stem Cells Derived Exosomes Improved The Aged Mouse IVM Oocytes Quality.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Good practice recommendations on add-ons in reproductive medicine†.Human reproduction (Oxford, England) · 2023Article
- The developmental competence of human metaphase I oocytes with delayed maturation in vitro.Fertility and sterility · 2023Article
- High efficiency of homemade culture medium supplemented with GDF9-β in human oocytes for rescue in vitro maturation.Clinical and experimental reproductive medicine · 2022Article
- Article
- In vitro maturation (IVM) of oocytes in patients with resistant ovary syndrome and in patients with repeated deficient oocyte maturation.Journal of assisted reproduction and genetics · 2018Article
- The Effects of In Vitro Maturation Technique on The Expression of Genes Involved in Embryonic Genome Activation of Human Embryos.Cell journal · 2018Article
- The potential role of granulosa cells in the maturation rate of immature human oocytes and embryo development: A co-culture study.Clinical and experimental reproductive medicine · 2015Article
- Amino acid turnover by human oocytes is influenced by gamete developmental competence, patient characteristics and gonadotrophin treatment.Human reproduction (Oxford, England) · 2013Article
- Embryological aspects of oocyte in vitro maturation.International journal of molecular and cellular medicine · 2013Review
- In-vitro maturation of human oocytes: before or after vitrification?Journal of assisted reproduction and genetics · 2012Article
- Release of superoxide dismutase-1 by day 3 embryos of varying quality and implantation potential.Journal of assisted reproduction and genetics · 2012Article
- The effect of human cumulus cells on the maturation and developmental potential of immature oocytes in ICSI cycles.Journal of assisted reproduction and genetics · 2012Article
- Maturation outcomes are improved following Cryoleaf vitrification of immature human oocytes when compared to choline-based slow-freezing.Journal of assisted reproduction and genetics · 2011Article
- In vitro maturation of germinal vesicle oocytes in stimulated intracytoplasmic sperm injection cycles.Cell journal · 2011Article
- The Effect of Human Chorionic Gonadotropin on theJournal of human reproductive sciencesArticle
- DECREASED FERTILIZATION: HUMAN SPERM DNA FRAGMENTATION ANDActa endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate 24 h in vitro maturation (IVM) of cumulus-stripped immature oocytes from stimulated cycles.
methods263 oocytes identified as immature after cumulus stripping for ICSI were subjected to in vitro maturation (IVM). Fertilization rates and reproductive outcomes of matured oocytes were compared against 234 in vivo matured sibling oocytes (IVO-MII-Sib) from the same cycles (n = 41). Day 2 embryo development was compared against 116 embryos from ICSI cycles having no IVM (IVO-Ext controls).
resultsWhile fertilization rates were similar between IVM and IVO-MII-Sib oocytes (62.1% vs. 64.0%, p = 0.9909), day 2 embryo quality was reduced in the IVM group compared with IVO-Ext controls as evidenced by fewer embryos having 4 cells (28.3% vs. 54.3%, p = 0.0026), low fragmentation (30.0% vs. 65.2%, p < 0.0001) or perfectly symmetric blastomeres (28.6% vs. 46.9%, p = 0.0371). 0 of 17 IVM embryos with known fate implanted.
conclusionEfficacy of 24 h IVM for cumulus-stripped GV and MI oocytes for either clinical use or study of normal meiotic maturation is questionable.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.