Evidence map›Paper›PMID 20425137›Full record

SynthesisEuropean journal of epidemiology2010

Metabolic syndrome and all-cause mortality: a meta-analysis of prospective cohort studies.

Sheng Hui Wu, Wu Sheng Hui, Zhong Liu, Suzanne C Ho

Erratum issuedAbstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 147 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 18 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pharmacological properties of ginger (Frontiers in pharmacology · 2025
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  6. Shift work and the risk for metabolic syndrome among healthcare workers: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
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  18. Metabolic syndrome and kidney disease: a systematic review and meta-analysis.Clinical journal of the American Society of Nephrology : CJASN · 2011
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
    Hui, Wu Sheng [corrected to Wu, Sheng Hui]
5 · Who and what money

Authors and funding

4 authors.

Sheng Hui WuSchool of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China. shenghuiwu@cuhk.edu.hk
Wu Sheng Hui
Zhong Liu
Suzanne C Ho

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To synthesize the available data on the association between metabolic syndrome and all-cause mortality, we conducted a meta-analysis of prospective cohort studies. We performed a literature search using Medline, EMBASE and Cochrane Library from 2001 to December 2009, with no restrictions. We included studies if they were prospective, had an assessment of metabolic syndrome at baseline and risk of all-cause mortality. We recorded several characteristics for each study. We extracted relative risks (RR) and 95% confidence intervals (CI) and pooled them using fixed or random effects models. We performed sensitivity analysis, and assessed heterogeneity and publication bias. A total of 21 studies including 372,411 participants were included in our meta-analysis. 18,556 deaths from any cause occurred during a mean follow-up of 11.5 years. Individuals with the metabolic syndrome, compared to those without, had an increased mortality from all causes (pooled RR 1.46; 95% CI 1.35-1.57). The RR of all-cause mortality associated with metabolic syndrome was higher in studies using the National Cholesterol Education Program Adult Treatment Panel (NCEP) than the revised NCEP criteria (RR: 1.45 vs. 1.25; P = 0.0002). Metabolic syndrome is an important risk factor for all-cause mortality. The diagnosis and treatment of the underlying risk factors for the metabolic syndrome should be an important strategy for the reduction of all-cause mortality associated with metabolic syndrome in the general population.

Indexed as

AdultCause of DeathCohort StudiesFemaleHumansMaleMetabolic SyndromeMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID20425137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.