ReviewCurrent osteoporosis reports2010
Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates.
Review in Current osteoporosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Comparison of bone turnover suppression in atypical femoral fractures and osteoporotic hip fractures.Scientific reports · 2024Article
- Breakage of intramedullary femoral nailing or femoral plating: how to prevent implant failure.European journal of medical research · 2022Article
- Peptidomimetic inhibitor of L-plastin reduces osteoclastic bone resorption in aging female mice.Bone research · 2021Article
- Beware of bone pain with bisphosphonates.BMJ case reports · 2019Article
- Prophylactic Fixation Can Be Cost-effective in Preventing a Contralateral Bisphosphonate-associated Femur Fracture.Clinical orthopaedics and related research · 2019Article
- Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro.International journal of cell biology · 2019Article
- Bone regeneration with umbilical cord blood mesenchymal stem cells in femoral defects of ovariectomized rats.Osteoporosis and sarcopenia · 2018Article
- Atraumatic femoral neck fracture during bisphosphonate treatment: case report and review of the literature.Aging clinical and experimental research · 2018Article
- Acetabular Insufficiency Fracture Following Prolonged Alendronate Use and the Failure of Total Hip Arthroplasty in "Frozen" Bone: Two Cases Report.Hip & pelvis · 2017Article
- Atypical femoral shaft fractures secondary to long-term bisphosphonate therapy.Journal of orthopaedics · 2017Article
- Factors Associated with Increased Healing Time in Complete Femoral Fractures After Long-Term Bisphosphonate Therapy.The Journal of bone and joint surgery. American volume · 2016Article
- Asperosaponin VI promotes bone marrow stromal cell osteogenic differentiation through the PI3K/AKT signaling pathway in an osteoporosis model.Scientific reports · 2016Article
- Stress fractures: pathophysiology, clinical presentation, imaging features, and treatment options.Emergency radiology · 2016Review
- BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study.Stem cells international · 2016Article
- Antiresorptive therapy and risk of mortality and refracture in osteoporosis-related hip fracture: a nationwide study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Atypical Complete Femoral Fractures Associated with Bisphosphonate Use or Not Associated with Bisphosphonate Use: Is There a Difference?BioMed research international · 2016Article
- [Atypical femoral fractures in bisphosphonate therapy].Der Unfallchirurg · 2015Article
- Atypical femur fractures: a review.Current osteoporosis reports · 2014Review
- Atypical femoral fractures in association with bisphosphonate therapy: a case series.Emergency radiology · 2014Article
- Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails.Clinical orthopaedics and related research · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several case series and multiple individual case reports suggest that some subtrochanteric and femoral shaft fractures might occur in patients who have been treated with long-term bisphosphonates. Several unique clinical and radiographic features are emerging: prodromal thigh pain prior to the fracture, complete absence of trauma precipitating the fracture, and bilateral fractures in some patients. Radiographic features include presence of stress reaction, transverse or short oblique fractures, and thick femoral cortices. The overall incidence of subtrochanteric and shaft fractures combined is below 30 per 100,000 person-years, so this type of fracture is much less common than proximal femur (hip) fracture. Furthermore, the unique "atypical" fracture type is a subset of all subtrochanteric and femoral shaft fractures. The putative mechanism is unknown, and more research is needed to identify distinctive characteristics and the pathophysiology of these atypical fractures. There is no rationale to withhold bisphosphonate therapy from patients with osteoporosis, although continued use of bisphosphonate therapy beyond a treatment period of 3 to 5 years should be re-evaluated annually.
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Registered trials
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