ReviewCurrent rheumatology reports2010
The role of uric acid and other crystals in osteoarthritis.
Review in Current rheumatology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Recent advances in nanocrystals for arthritis drug delivery.Expert opinion on drug delivery · 2025Review
- Applications of dual-energy CT in acute musculoskeletal and trauma imaging-a review.Skeletal radiology · 2024Review
- Correlations of characteristics with tissue involvement in knee gouty arthritis: Magnetic resonance imaging analysis.Heliyon · 2024Article
- Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study.Life (Basel, Switzerland) · 2023Article
- Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes : Secretome of synoviocytes induces chondrocyte damage.Clinical rheumatology · 2021Article
- Chondrocalcinosis is associated with increased knee joint degeneration over 4 years: data from the Osteoarthritis Initiative.Osteoarthritis and cartilage · 2020Article
- Patients With Rheumatoid Arthritis Increased Risk of Developing Osteoarthritis: A Nationwide Population-Based Cohort Study in Taiwan.Frontiers in medicine · 2020Article
- Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.BMC complementary and alternative medicine · 2019Article
- Evaluation of Chondrocalcinosis and Associated Knee Joint Degeneration Using MR Imaging: Data from the Osteoarthritis Initiative.European radiology · 2017Article
- Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Gout and Osteoarthritis: Associations, Pathophysiology, and Therapeutic Implications.Current rheumatology reports · 2016Review
- The associations of serum uric acid level and hyperuricemia with knee osteoarthritis.Rheumatology international · 2016Article
- The prevalence of monosodium urate and calcium pyrophosphate crystals in synovial fluid from wrist and finger joints.Rheumatology international · 2016Observational
- Dual-energy CT for the diagnosis of gout: an accuracy and diagnostic yield study.Annals of the rheumatic diseases · 2015Article
- Presence of gout is associated with increased prevalence and severity of knee osteoarthritis among older men: results of a pilot study.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2015Article
- Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study.Arthritis research & therapy · 2015Article
- Headaches related to rheumatologic disease.Current pain and headache reports · 2013Review
- Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.Arthritis and rheumatism · 2012Article
- Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status.Metabolomics : Official journal of the Metabolomic Society · 2012Article
- Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population.American journal of epidemiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinicians have long assumed that an association exists between crystal arthropathies and the presence of osteoarthritis (OA). However, studies establishing an independent association between calcium pyrophosphate or uric acid crystal disease and OA are sparse. Even less is known about a possible pathogenic relationship. Whereas some studies suggest that the relationships between crystals and OA may not be incidental and that crystal deposition may contribute to the onset and/or acceleration of OA joint damage, other authors have challenged this assertion. In this review, we provide an overview of past and current research elucidating the role of crystal deposition, including monosodium urate, calcium pyrophosphate, and other crystals, in OA. Given the clinical frequency of gout and that agents exist to modulate serum UA levels, special attention is given to the role of monosodium urate crystals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.