ReviewCurrent rheumatology reports2010
Gout, hyperuricemia, and the risk of cardiovascular disease: cause and effect?
Review in Current rheumatology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Serum uric acid and prognosis of ischemic stroke: Cohort study, meta-analysis and Mendelian randomization study.European stroke journal · 2024Pooled it
- Evaluation of the Safety, Tolerability, Pharmacokinetics, and Efficacy of Subcutaneous Firsekibart in Gout: A Phase Ib/II Clinical Trial.International journal of rheumatic diseases · 2026Trial
- Hyperuricemia and the risk of stroke incidence and mortality: A systematic review and meta-analysis.Archives of rheumatology · 2025Review
- Moxibustion inhibits inflammation in monosodium urate crystal-induced gouty arthritis model rats through metabolomic regulation.Frontiers in molecular biosciences · 2025Article
- Impact ofNutrients · 2021Article
- Review
- Epidemiology of cardiac or orthopedic procedures in goutTherapeutic advances in musculoskeletal disease · 2021Article
- Gout and Progression of Aortic Stenosis.The American journal of medicine · 2020Observational
- Assessment of the efficacy of hemodialysis on uric acid clearance in a sub-Saharan African population at the end stage kidney disease.BMC nephrology · 2020Article
- U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.Upsala journal of medical sciences · 2020Article
- Association of overweight and obesity with cardiovascular risk factors in patients with atherosclerotic diseases.Journal of medical biochemistry · 2020Article
- An examination of the relationship between serum uric acid level, a clinical history of gout, and cardiovascular outcomes among patients with acute coronary syndrome.American heart journal · 2017Article
- Effects of febuxostat on insulin resistance and expression of high-sensitivity C-reactive protein in patients with primary gout.Rheumatology international · 2017Article
- Association Between Gout and Aortic Stenosis.The American journal of medicine · 2017Article
- Article
- Hypouricemic effect of flaccidoside II in rodents.Journal of natural medicines · 2017Article
- Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levels.Circulation. Cardiovascular genetics · 2014Article
- Risk factors for incident hyperuricemia during mid-adulthood in African American and white men and women enrolled in the ARIC cohort study.BMC musculoskeletal disorders · 2013Article
- Factors associated with gout in South Koreans: analysis using the National Health Insurance Corporation and the National Health Screening Exam databases.Clinical rheumatology · 2013Article
- A profile of gout patients in Sarawak.Rheumatology international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gout and hyperuricemia have long been suspected to be risk factors for cardiovascular disease. However, studies have frequently failed to distinguish whether these entities have an independent effect on cardiovascular risk or serve as markers for other risk factors. In vitro and animal studies suggest that uric acid is a biologically active compound that can increase inflammatory mediators known to lead to vascular damage. In contrast, uric acid also has potentially protective effects as a strong antioxidant, approaching the potency of vitamin C. Large clinical trials demonstrate a consistent relationship between elevated serum uric acid and a variety of cardiovascular diseases, although the strength of association varies greatly. We review the evidence for and against an independent role for hyperuricemia and/or gout in cardiovascular pathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.