Evidence map›Paper›PMID 20425016›Full record

ReviewCurrent rheumatology reports2010

The genetics of juvenile idiopathic arthritis: what is new in 2010?

Sheila Angeles-Han, Sampath Prahalad

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. An Update on Treatment of Pediatric Chronic Non-Infectious Uveitis.Current treatment options in rheumatology · 2017
    Article
  4. Article
  5. Article
  6. Article
  7. CLARITY - ChiLdhood Arthritis Risk factor Identification sTudY.Pediatric rheumatology online journal · 2012
    Article
  8. Synovium, synergy and serendipity.Journal of inherited metabolic disease · 2011
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sheila Angeles-HanDepartment of Pediatrics, Emory University School of Medicine, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA.
Sampath Prahalad
Emory University · US

Funding

Genetic variation in T-cell regulatory molecules and JRAK23AR050177 · NIAMS · UNIVERSITY OF UTAH · PI PRAHALAD, SAMPATH · 2004 to 2008
$674k
NIAMS NIH HHS K23 AR050177NIAMS NIH HHS K23-AR50177
6 · The paper itself

Abstract

Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is believed to be influenced by genetic factors. Recent studies on the genetics of JIA have not only validated proposed genetic associations but have also led to the recognition of novel genetic associations. Studies of specific genes have been modeled on the premise of shared autoimmunity, wherein genetic variants that predispose to other autoimmune phenotypes may also confer susceptibility to JIA. The advent of genome-wide association studies has accelerated the detection of non-HLA susceptibility loci in other autoimmune phenotypes and is likely to uncover novel JIA-associated variants as well. This review highlights recent genetic investigations of JIA.

Indexed as

AdolescentArthritis, JuvenileAutoimmunityChildChild, PreschoolDNA-Binding ProteinsFemaleGenetic Predisposition to DiseaseHumansInterleukin-2 Receptor alpha SubunitIntracellular Signaling Peptides and ProteinsMaleNuclear ProteinsSTAT4 Transcription FactorTNF Receptor-Associated Factor 1Tumor Necrosis Factor alpha-Induced Protein 3DNA-Binding ProteinsIL2RA protein, humanInterleukin-2 Receptor alpha SubunitIntracellular Signaling Peptides and ProteinsNuclear ProteinsSTAT4 protein, humanSTAT4 Transcription FactorTNFAIP3 protein, humanTNF Receptor-Associated Factor 1Tumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID20425016
OpenAlexW2128193788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.