ArticleMedical & biological engineering & computing2010
The influence of skeletal muscle anisotropy on electroporation: in vivo study and numerical modeling.
Article in Medical & biological engineering & computing, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Computational Multiscale Modeling of Pulsed Field Ablation Considering Conductivity and Damage Anisotropy Reveals Deep Lesion Morphologies.International journal for numerical methods in biomedical engineering · 2025Article
- Is a single lethal electric field threshold sufficient to characterize the lesion size in computational modeling of cardiac pulsed-field ablation?Heart rhythm O2 · 2025Article
- Advances in irreversible electroporation for prostate cancer.Discover oncology · 2024Review
- Finite Element Evaluation of the Electric Field Distribution in a Non-Homogeneous Environment.Bioengineering (Basel, Switzerland) · 2023Article
- 704/DNA vaccines leverage cytoplasmic DNA stimulation to promote anti-HIV neutralizing antibody production in mice and strong immune response against alpha-fetoprotein in non-human primates.Molecular therapy. Nucleic acids · 2023Article
- Determination of lethal electric field threshold for pulsed field ablation inFrontiers in cardiovascular medicine · 2023Article
- Reversible and Irreversible Effects of Electroporation on Contractility and Calcium Homeostasis in Isolated Cardiac Ventricular Myocytes.Circulation. Arrhythmia and electrophysiology · 2022Article
- Effects of Electrode-Tissue Proximity on Cardiac Lesion Formation Using Pulsed Field Ablation.Circulation. Arrhythmia and electrophysiology · 2022Article
- A personalized FEM model for reproducible measurement of anti-inflammatory drugs in transdermal administration to knee.Scientific reports · 2022Article
- Electroporation-Based Treatments in Urology.Cancers · 2020Review
- Short microsecond pulses achieve homogeneous electroporation of elongated biological cells irrespective of their orientation in electric field.Scientific reports · 2020Article
- The Efficiency of Gene Electrotransfer in Breast-Cancer Cell Lines Cultured on a Novel Collagen-Free 3D Scaffold.Cancers · 2020Article
- AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study.Frontiers in bioengineering and biotechnology · 2020Article
- Effects of electrically-induced constant tension on giant unilamellar vesicles using irreversible electroporation.European biophysics journal : EBJ · 2019Article
- Article
- Effect of Electrode Distance in Grid Electrode: Numerical Models and In Vitro Tests.Technology in cancer research & treatment · 2018Article
- Effect of Tissue Inhomogeneity in Soft Tissue Sarcomas: From Real Cases to Numerical and Experimental Models.Technology in cancer research & treatment · 2018Article
- Microscopic histological characteristics of soft tissue sarcomas: analysis of tissue features and electrical resistance.Medical & biological engineering & computing · 2017Article
- Mapped Chebyshev pseudo-spectral method for simulating the shear wave propagation in the plane of symmetry of a transversely isotropic viscoelastic medium.Medical & biological engineering & computing · 2017Article
- Evaluation of Soft Tissue Sarcoma Tumors Electrical Conductivity Anisotropy Using Diffusion Tensor Imaging for Numerical Modeling on Electroporation.Journal of biomedical physics & engineering · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to theoretically and experimentally investigate electroporation of mouse tibialis cranialis and to determine the reversible electroporation threshold values needed for parallel and perpendicular orientation of the applied electric field with respect to the muscle fibers. Our study was based on local electric field calculated with three-dimensional realistic numerical models, that we built, and in vivo visualization of electroporated muscle tissue. We established that electroporation of muscle cells in tissue depends on the orientation of the applied electric field; the local electric field threshold values were determined (pulse parameters: 8 x 100 micros, 1 Hz) to be 80 V/cm and 200 V/cm for parallel and perpendicular orientation, respectively. Our results could be useful electric field parameters in the control of skeletal muscle electroporation, which can be used in treatment planning of electroporation based therapies such as gene therapy, genetic vaccination, and electrochemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.