ArticlePharmaceutical research2010
Liposomes coloaded with iopamidol/lipiodol as a RES-targeted contrast agent for computed tomography imaging.
Article in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 57 citations in OpenAlex.
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- The Usefulness of Nanotechnology in Improving the Prognosis of Lung Cancer.Biomedicines · 2023Review
- Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging.Molecules (Basel, Switzerland) · 2021Review
- Nanotechnology and its use in imaging and drug delivery (Review).Biomedical reports · 2021Review
- Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging.Scientific reports · 2018Article
- A Novel Nano-approach for Targeted Inner Ear Imaging.Journal of nanomedicine & nanotechnology · 2017Article
- Development of individualized anti-metastasis strategies by engineering nanomedicines.Chemical Society reviews · 2015Review
- Computed tomography-guided screening of surfactant effect on blood circulation time of emulsions: application to the design of an emulsion formulation for paclitaxel.Pharmaceutical research · 2014Article
- Article
- Iodinated oil-loaded, fluorescent mesoporous silica-coated iron oxide nanoparticles for magnetic resonance imaging/computed tomography/fluorescence trimodal imaging.International journal of nanomedicine · 2014Article
- Nanotechnology for computed tomography: a real potential recently disclosed.Pharmaceutical research · 2014Review
- Bismuth@US-tubes as a Potential Contrast Agent for X-ray Imaging Applications.Journal of materials chemistry. B · 2013Article
- X-ray-computed tomography contrast agents.Chemical reviews · 2013Review
- The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma.Biomaterials · 2011Article
- Multicolor computed tomographic molecular imaging with noncrystalline high-metal-density nanobeacons.Contrast media & molecular imagingReview
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe need for computed tomography (CT) of reticuloendothelial system (RES)-rich organs such as the liver is increasing, particularly in patients with suspected hepatic metastasis. CT images of the liver have been improved by encapsulating currently used, water-soluble iodine contrast agent in liposomes. The present study was performed to investigate a possibility to overcome the limitations of entrapped iodine in liposomes by preparing liposomes co-loaded with iopamidol, a water-soluble iodinated compound, and lipiodol, an iodized oil.
methodsIopamidol and lipiodol were simultaneously loaded in liposomes by modified reverse-phase evaporation method. The entrapped iodine concentration, mean particle size and polydispersity index of resulting liposomes were evaluated. Following intravenous injection of these liposomes into rats, CT scanning was performed.
resultsSimultaneous loading of iopamidol and lipiodol into liposomes resulted in entrapped iodine concentrations as high as 49.2 iodine mg/ml. The mean particle size was 280 nm, and the mean polydispersity index was 0.230. CT scanning with these iopamidol/lipiodol (I/L) liposomes into rats resulted in more pronounced and more persistent increases in RES-rich organs, liver and spleen, compared with free liposomes or liposomes loaded with iopamidol alone.
conclusionsThese findings indicate that I/L liposomes have the potential to allow thorough CT examination of RES-rich organs.
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