ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2011
Healing action of topical chamomile on 5-fluoracil induced oral mucositis in hamster.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Evaluation of the therapeutic effects of the topical and systemic forms of Honokiol in 5-fluorouracil-induced oral mucositis model in rats.Scientific reports · 2025Article
- Association between fear of cancer recurrence and emotional distress in breast cancer: a latent profile and moderation analysis.Frontiers in psychiatry · 2025Article
- Review
- Palliative oral care in terminal cancer patients: Integrated review.World journal of clinical cases · 2023Article
- Evaluation of the effect of Matricaria recutita monotherapy or in combination with photodynamic therapy on tissue repair in the dorsum of the tongue of rats.Journal of applied oral science : revista FOB · 2023Article
- Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy.Oncotarget · 2021Article
- Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile,Biomolecules · 2019Review
- Effects ofTheScientificWorldJournal · 2018Review
- Radiation-Induced Oral Mucositis.Frontiers in oncology · 2017Review
- Topical Olive Leaf Extract Improves Healing of Oral Mucositis in Golden Hamsters.Journal of dentistry (Shiraz, Iran) · 2016Article
- A New mouthwash for Chemotherapy Induced Stomatitis.Nursing and midwifery studies · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral mucositis is a common complication in the treatment of cancer. Its management and prevention are seen as high priority in cancer patient care. The aim of the present study was to investigate the effect of topical chamomile in the treatment of oral mucositis induced by 5-fluoracil (5-FU) in hamsters. MATERIALS AND
methodsOne hundred five hamsters were randomly separated into three groups (35 animals each): group I--without treatment (control); group II--treatment with chamomile (Ad-Muc®); and group III--treatment with corticoid (betamethasone elixir--Celestone®). The animals received an intraperitoneal injection of 5-FU on days 0 and 2. On days 3 and 4, the buccal mucosa was scratched and therapy was initiated on day 5. Three animals were sacrificed on days 0, 2, 5, 8, 10, 12, 14, and 16, weighed, and the buccal mucosa removed for clinical and histopathological analysis.
resultsThe animals that developed mucositis and were treated with chamomile or the corticoid agent weighed significantly less than those in the control group. The group treated with the corticoid agent exhibited a more severe clinical condition, whereas the group treated with chamomile exhibited mild mucositis throughout the experiment. The group treated with chamomile had a 12-fold greater chance of scoring zero (absence of mucositis) than the control group. Analysis of the histopathological results demonstrated that the group treated with chamomile exhibited a lesser degree of mucositis throughout the evaluation period in comparison to the control and corticoid groups.
conclusionChamomile proved effective in the treatment of oral mucositis in a hamster model. However, well-designed clinical studies are needed to confirm the clinical efficacy of this medicine in humans.
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