Evidence map›Paper›PMID 20424852›Full record

Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2010

Safety and feasibility of a novel intravitreal tamponade using a silicone oil/acetyl-salicylic acid suspension for proliferative vitreoretinopathy: first results of the Austrian Clinical Multicenter Study.

Martina Theresa Kralinger, Ulrike Stolba, Michaela Velikay, Stefan Egger, Susanne Binder, Andreas Wedrich, Anton Haas, Jean-Marie Parel, Gerhard Franz Kieselbach

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01681615 (Challenge Test for Acetylsalicylic Acid Hypersensitivity), which is not on this map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01681615 naunknown statusnot on this mapstarted 2012, after this paper: background citation

Challenge Test for Acetylsalicylic Acid Hypersensitivity

TypeinterventionalSponsorHelse Stavanger HFRan2012 to 2013Enrolled50ConditionsAsthma Aspirin-sensitive, ASA Intolerant Asthma, Asthma, Aspirin-Induced, Asthma, Nasal Polyps, and Aspirin IntoleranceArmsAcetylsalicylate, Isotonic NaCl
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Vitreous Substitutes as Drug Release Systems.Translational vision science & technology · 2022
    Review
  5. Modulated release from implantable ocular silicone oil tamponade drug reservoirs.Journal of polymer science. Part A, Polymer chemistry · 2018
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

Martina Theresa KralingerDepartment of Ophthalmology, Innsbruck Medical University, Innsbruck, Austria. martina.kralinger@i-med.ac.at
Ulrike Stolba
Michaela Velikay
Stefan Egger
Susanne Binder
Andreas Wedrich
Anton Haas
Jean-Marie Parel
Gerhard Franz Kieselbach
Medical University of Graz · ATInnsbruck Medical University · ATKrankenanstalt Rudolfstiftung der Stadt Wien · ATHôtel-Dieu de Paris · FRUniversity of Salzburg · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe safety and efficacy of a new surgical method of intravitreal tamponade using silicone oil suspended with aspirin (acetylsalicylic acid) was investigated for the treatment of proliferative vitreoretinopathy.

methodsThe study was designed as a prospective, randomized, controlled, double-blind multicenter study. A total of 29 patients were included; 15 patients were treated with the silicone oil suspended with aspirin, and 14 patients represented the control group receiving only silicone oil. A standard three-port pars plana vitrectomy was performed in 29 eyes of 29 patients. In cases in which the natural lens was present, simultaneous phacoemulsification was required. The control group received as standard therapy a vitreous tamponade with pure 5000 mPas silicone oil and the treatment group received silicone oil containing 0.2 mg/ml aspirin (AS SiO). At 6 months after surgery, the tamponade was removed from all eyes. The main outcome measure was the incidence of retinal redetachment requiring reoperation. Secondary outcome measures were visual acuity and ophthalmic examination results.

resultsThe rate of redetachment, defined as the primary outcome parameter, was the same for both groups. The AS SiO was well tolerated and remained clear during the 6-month study period. Clinical examination revealed no signs of local or systemic adverse effects. The visual acuities were well matched before inclusion in the study and there were no significant differences during the follow-up period and in the final visual outcome between the two groups.

conclusionsAspirin delivery by intravitreal silicone oil in the human eye is safe and also may provide a delivery vehicle for other antiproliferative agents to the posterior pole.

Indexed as

AdultAgedAged, 80 and overAspirinAustriaDouble-Blind MethodDrainageDrug CombinationsFeasibility StudiesFemaleHumansMaleMiddle AgedPhacoemulsificationPrognosisProspective StudiesAspirinDrug CombinationsSilicone Oils

Identifiers

PMID20424852
OpenAlexW2021709137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.