ArticlePsychopharmacology2010
Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humans.
Article in Psychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Should perception of emotions be classified according to threat detection rather than emotional valence? An updated meta-analysis for a whole-brain atlas of emotional faces processing.Journal of psychiatry & neuroscience : JPNPooled it
- The behavioural effects of the serotonin 1A receptor agonist buspirone on cognition and emotional processing in healthy volunteers.Psychopharmacology · 2025Trial
- Serotonin differentially modulates the temporal dynamics of the limbic response to facial emotions in male adults with and without autism spectrum disorder (ASD): a randomised placebo-controlled single-dose crossover trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Trial
- Effects of acute tryptophan depletion on prefrontal-amygdala connectivity while viewing facial signals of aggression.Biological psychiatry · 2012Trial
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- RETRACTED: Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Opposing Cholinergic and Serotonergic Modulation of Layer 6 in Prefrontal Cortex.Frontiers in neural circuits · 2017Article
- Effects of acute tryptophan depletion on raphé functional connectivity in depression.Psychiatry research · 2015Article
- Response inhibition and serotonin in autism: a functional MRI study using acute tryptophan depletion.Brain : a journal of neurology · 2014Article
- Effects of acute alcohol consumption and processing of emotion in faces: Implications for understanding alcohol-related aggression.Journal of psychopharmacology (Oxford, England) · 2014Review
- Piccolo genotype modulates neural correlates of emotion processing but not executive functioning.Translational psychiatry · 2012Article
- Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants.Psychopharmacology · 2011Article
- Brain serotonergic circuitries.Dialogues in clinical neuroscience · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute tryptophan depletion (ATD) temporarily lowers brain serotonin (5-HT) synthesis, and behavioral studies have shown that this alters the processing of facial expressions of emotion. MATERIALS AND
methodsThe neural basis for these alterations is not known. Therefore, we employed ATD and event-related functional magnetic resonance imaging (fMRI) to examine neural responses during incidental processing of fearful, happy, sad, and disgusted facial expressions. Fourteen healthy male controls (age, 28 +/- 10) were scanned under both placebo (SHAM) and depletion (ATD) conditions. RESULTS AND DISCUSSION: We predicted that ATD would be associated with changes in neural activity within facial emotion-processing networks. We found that serotonergic modulation did not affect performance on the fMRI tasks, but was associated with widespread effects on neural response to components of face processing networks for fearful, disgusted, and happy but not sad expressions across differing intensities.
conclusionHence, the 5-HT system affects brain function (in 'limbic' and 'face processing' regions) during incidental processing of emotional facial expressions; but this varies with emotion type and intensities.
Indexed as
Identifiers
20424829What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.