ArticleBlood2010
Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- HIV-1 adapts to HLA class II-associated selection pressure exerted by CD4Science advances · 2025Article
- T-cell receptor architecture and clonal tiding provide insight into the transformation trajectory of peripheral T-cell lymphomas.Haematologica · 2025Article
- The role of TEMRA cell-mediated immune senescence in the development and treatment of HIV disease.Frontiers in immunology · 2023Review
- Mapping and Characterization of HCMV-Specific Unconventional HLA-E-Restricted CD8 T Cell Populations and Associated NK and T Cell Responses Using HLA/Peptide Tetramers and Spectral Flow Cytometry.International journal of molecular sciences · 2021Article
- Article
- Review
- Partial recovery of senescence and differentiation disturbances in CD8Clinical and experimental immunology · 2016Article
- Multiparameter analysis of stimulated human peripheral blood mononuclear cells: A comparison of mass and fluorescence cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2016Article
- Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Relationships of pulmonary function, inflammation, and T-cell activation and senescence in an HIV-infected cohort.AIDS (London, England) · 2014Article
- High frequencies of polyfunctional CD8+ NK cells in chronic HIV-1 infection are associated with slower disease progression.Journal of virology · 2014Article
- Article
- Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis.Arthritis and rheumatism · 2013Article
- Antiretroviral therapy reduces the magnitude and T cell receptor repertoire diversity of HIV-specific T cell responses without changing T cell clonotype dominance.Journal of virology · 2012Article
- Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Flexibility of the HIV-specific T-cell receptor repertoire is a hallmark of HIV-1 infection. Altered differentiation of HIV-specific CD45RO(+)/CCR7(-) (TemRO) CD8(+) effector-memory T cells into CD45RA(+)/CCR7(-) (TemRA) CD8(+) effector-memory T cells as well as increased expression of the senescence marker CD57 has been frequently observed HIV-1 infection, but the structural relationship between clonal expansion and T-cell differentiation has not been defined. In this study, we demonstrate that HIV-specific clonotypes have differing degrees of TemRA differentiation but always maintain a significant proportion of TemRO-phenotype cells. These data indicate that structural constraints of the TCR/peptide major histocompatibility complex interaction play a central role in the TemRA differentiation of HIV-specific CD8(+) T cells in chronic HIV-1 infection. Clonotypes with a predominantly TemRA phenotype had a substantial fraction of cells without expression of CD57; and in contrast to the high clonotypic variability of TemRA differentiation, expression of CD57 was highly correlated among T-cell clonotypes within epitope-specific responses, indicating TCR-independent expression of CD57 in vivo. Our data highlight the importance of the structural composition of the TCR repertoire for the effector-memory differentiation of the immune response in chronic viral infections and suggest that TCR-dependent and -independent homeostasis shapes the pathogen-specific effector-memory repertoire in vivo.
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