ArticleThe Plant cell2010
Sulfite reductase defines a newly discovered bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 178 citations in OpenAlex.
- The Cytosolic Iron-Sulfur Cluster Assembly Targeting Complex Is Hijacked by Magnaporthe Effector AvrPi9 to Suppress Rice Resistance.Plant biotechnology journal · 2026Article
- Organelle-specific hydrogen sulfide metabolism governs redox homeostasis to regulate plant autophagy and cadmium stress resilience.Redox biology · 2026Article
- An atlas of plant selenium metabolism.The New phytologist · 2026Review
- From odor to order: unveiling the crucial role of hydrogen sulfide in plant life.Horticulture research · 2026Article
- Cystathionine β-synthase TtCbs1 fromApplied and environmental microbiology · 2025Article
- A transcription factor ensemble orchestrates bundle sheath expression in rice.Nature communications · 2025Article
- Comprehensive identification, stress responses and protein-protein interactions of the ferredoxin gene family in the fast-growing tree species Paulownia fortunei.BMC plant biology · 2025Article
- Hydrogen sulfide in plant cold stress: functions, mechanisms, and challenge.Plant molecular biology · 2024Review
- Catalysts for sulfur: understanding the intricacies of enzymes orchestrating plant sulfur anabolism.Planta · 2024Review
- Analysis of the quadruple lsu mutant reveals molecular determinants of the role of LSU proteins in sulfur assimilation in Arabidopsis.The Plant journal : for cell and molecular biology · 2024Article
- Chloroplastic ascorbate modifies plant metabolism and may act as a metabolite signal regardless of oxidative stress.Plant physiology · 2024Article
- The plant TOR kinase tunes autophagy and meristem activity for nutrient stress-induced developmental plasticity.The Plant cell · 2022Article
- Cyanide Biodegradation byMolecules (Basel, Switzerland) · 2022Article
- Sulfur signaling and starvation response in Arabidopsis.iScience · 2022Review
- Redox regulation of enzymes involved in sulfate assimilation and in the synthesis of sulfur-containing amino acids and glutathione in plants.Frontiers in plant science · 2022Review
- Discriminative Long-Distance Transport of Selenate and Selenite Triggers Glutathione Oxidation in Specific Subcellular Compartments of Root and Shoot Cells inFrontiers in plant science · 2022Article
- Crosstalk Between Iron and Sulfur Homeostasis Networks inFrontiers in plant science · 2022Article
- Sulfur Compounds in Regulation of Stomatal Movement.Frontiers in plant science · 2022Review
- Coordinated bacterial and plant sulfur metabolism inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Rice Ferredoxins localize to chloroplasts/plastids and may function in different tissues.Plant signaling & behavior · 2021Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of sulfite reductase (SiR) in assimilatory reduction of inorganic sulfate to sulfide has long been regarded as insignificant for control of flux in this pathway. Two independent Arabidopsis thaliana T-DNA insertion lines (sir1-1 and sir1-2), each with an insertion in the promoter region of SiR, were isolated. sir1-2 seedlings had 14% SiR transcript levels compared with the wild type and were early seedling lethal. sir1-1 seedlings had 44% SiR transcript levels and were viable but strongly retarded in growth. In mature leaves of sir1-1 plants, the levels of SiR transcript, protein, and enzymatic activity ranged between 17 and 28% compared with the wild type. The 28-fold decrease of incorporation of (35)S label into Cys, glutathione, and protein in sir1-1 showed that the decreased activity of SiR generated a severe bottleneck in the assimilatory sulfate reduction pathway. Root sulfate uptake was strongly enhanced, and steady state levels of most of the sulfur-related metabolites, as well as the expression of many primary metabolism genes, were changed in leaves of sir1-1. Hexose and starch contents were decreased, while free amino acids increased. Inorganic carbon, nitrogen, and sulfur composition was also severely altered, demonstrating strong perturbations in metabolism that differed markedly from known sulfate deficiency responses. The results support that SiR is the only gene with this function in the Arabidopsis genome, that optimal activity of SiR is essential for normal growth, and that its downregulation causes severe adaptive reactions of primary and secondary metabolism.
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