ArticleCancer prevention research (Philadelphia, Pa.)2010
Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice.
Article in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Chronic psychosocial stress: a role in breast cancer etiology?Frontiers in oncology · 2026Pooled it
- Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- Stress and cancer: mechanisms, significance and future directions.Nature reviews. Cancer · 2021Review
- A Novel Effect of β-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer.Journal of mammary gland biology and neoplasia · 2017Article
- Black-White Disparities in Breast Cancer Subtype: The Intersection of Socially Patterned Stress and Genetic Expression.AIMS public health · 2017Article
- Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk.Endocrine-related cancer · 2016Article
- Article
- Social environmental effects on gene regulation.Cellular and molecular life sciences : CMLS · 2013Review
- Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- Early impact of social isolation and breast tumor progression in mice.Brain, behavior, and immunity · 2013Article
- Effects of enriched environment on COX-2, leptin and eicosanoids in a mouse model of breast cancer.PloS one · 2012Article
- Stress and breast cancer: from epidemiology to molecular biology.Breast cancer research : BCR · 2011Review
- Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer.Breast cancer research : BCR · 2011Article
- Psychosocially influenced cancer: diverse early-life stress experiences and links to breast cancer.Cancer prevention research (Philadelphia, Pa.) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Chronic stress is associated with more rapid tumor progression, and recent evidence suggests that stress may contribute to social and ethnic disparities in the incidence and mortality of breast cancer. We evaluated the p53(+/-) FVB/N mouse as a model to investigate effects of chronic social stress on mammary gland development, gene expression, and tumorigenesis. We individually housed (IH) wild-type and p53(+/-) female FVB/N mice, starting at weaning. At 14 weeks of age, both wild-type and p53(+/-) IH mice showed strikingly reduced mammary development compared with group-housed (GH) controls, with IH mice having significantly fewer preterminal end buds. This morphologic difference was not reflected in levels of mammary transcripts for estrogen receptor-alpha or progestin receptor. However, IH increased levels of mRNA for the kisspeptin receptor in the medial preoptic area of the hypothalamus, associated with reduced duration of estrous cycles. Furthermore, IH altered mammary transcripts of genes associated with DNA methylation; transcripts for methyl-binding protein 2 and DNA methyltransferase 3b (DNMT3b), but not DNMT1 and DNMT3a, were reduced in IH compared with GH females. Interestingly, the glands of p53(+/-) females showed reduced expression of all these mediators compared with wild-type females. However, contrary to our initial hypothesis, IH did not increase mammary tumorigenesis. Rather, p53(+/-) GH females developed significantly more mammary tumors than IH mice. Together, these data suggest that social isolation initiated at puberty might confound studies of tumorigenesis by altering mammary development in mouse models.
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Registered trials
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