ArticlePhysiological genomics2010
Quantitative trait loci associated with murine central corneal thickness.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Ethnic and mouse strain differences in central corneal thickness and association with pigmentation phenotype.PloS one · 2011Pooled it
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- Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.PLoS genetics · 2018Article
- Genetics in Keratoconus - What is New?The open ophthalmology journal · 2017Article
- Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Experimental eye research · 2015Review
- Genetic Evidence for Differential Regulation of Corneal Epithelial and Stromal Thickness.Investigative ophthalmology & visual science · 2015Article
- Ketamine/Xylazine-Induced Corneal Damage in Mice.PloS one · 2015Article
- Genetic and genomic perspective to understand the molecular pathogenesis of keratoconus.Indian journal of ophthalmology · 2013Review
- The Genetics of Keratoconus: A Review.Reproductive system & sexual disorders : current research · 2012Article
- Differences in corneal phenotypes between destrin mutants are due to allelic difference and modified by genetic background.Molecular vision · 2012Article
- Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.The Journal of clinical investigation · 2011Article
- Noninvasive assessment of vascular structure and function in conscious rats based on in vivo imaging of the albino iris.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The cornea is a specialized transparent tissue responsible for refracting light, serving as a protective barrier, and lending structural support to eye shape. Given its importance, the cornea exhibits a surprising amount of phenotypic variability in some traits, including central corneal thickness (CCT). More than a mere anatomic curiosity, differences in CCT have recently been associated with risk for glaucoma. Although multiple lines of evidence support a strong role for heredity in regulating CCT, the responsible genes remain unknown. To better understand the genetic basis of CCT variability, we conducted a genomewide quantitative trait locus (QTL) analysis with (C57BLKS/J x SJL/J) F(2) mice. This experiment identified a locus, Cctq1 (central corneal thickness QTL 1) on chromosome 7 (Chr 7; peak, 105 Mb), that is significantly associated with CCT. To independently test the biological significance of these results, (C57BLKS/J x NZB/B1NJ) F(2) mice were generated and analyzed for associations with Chr 7. This experiment identified a significant association at 131 Mb. Furthermore, low-generation congenic mice in which the Chr 7 QTL interval from the SJL strain was transferred onto the KS background had CCT values significantly higher than inbred KS mice. These results demonstrate that the genetic dependence of CCT in mice is a multigenic trait, which in these contexts is significantly regulated by a region on Chr 7. Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.