Evidence map›Paper›PMID 20423721›Full record

ArticleNeuroscience2010

Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model.

C H Chen, A Manaenko, Y Zhan, W W Liu, R P Ostrowki, J Tang, J H Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. The Protective Role of Molecular Hydrogen in Ischemia/Reperfusion Injury.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

C H ChenDepartment of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA.
A Manaenko
Y Zhan
W W Liu
R P Ostrowki
J Tang
J H Zhang
Loma Linda University · USPeking University · CN

Funding

Mechanisms of Hyperbaric Oxygen Induced Brain ProtectionR01NS043338 · NINDS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H · 2004 to 2014
$3.0M
Neurovascular Protection for Subarachnoid HemorrhageR01NS053407 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2006 to 2010
$1.8M
Oxygen Therapy in Neonatal Hypoxia-IschemiaR01HD043120 · NICHD · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ZHANG, JOHN H. · 2003 to 2007
$1.6M
NICHD NIH HHS R01 HD043120NINDS NIH HHS NS43338NINDS NIH HHS NS53407NINDS NIH HHS R01 NS043338NINDS NIH HHS R01 NS053407
6 · The paper itself

Abstract

Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model. Sprague-Dawley rats (n=72) were divided into the following groups: sham; sham treated with hydrogen gas (H(2)); Middle Cerebral Artery Occlusion (MCAO); and MCAO treated with H(2) (MCAO+H(2)). All rats received an injection of 50% dextrose (6 ml/kg i.p.) and underwent MCAO 15 min later. Following a 90 min ischemic period, hydrogen was inhaled for 2 h during reperfusion. We measured the level of blood glucose at 0 h, 0.5 h, 4 h, and 6 h after dextrose injection. Infarct and hemorrhagic volumes, neurologic score, oxidative stress (evaluated by measuring the level of 8 Hydroxyguanosine (8OHG), 4-Hydroxy-2-Nonenal (HNE) and nitrotyrosine), and matrix metalloproteinase (MMP)-2/MMP-9 activity were measured at 24 h after ischemia. We found that hydrogen inhalation for 2 h reduced infarct and hemorrhagic volumes and improved neurological functions. This effect of hydrogen was accompanied by a reduction of the expression of 8OHG, HNE, and nitrotyrosine and the activity of MMP-9. Furthermore, a reduction of the blood glucose level from 500+/-32.51 to 366+/-68.22 mg/dl at 4 h after dextrose injection was observed in hydrogen treated animals. However, the treatment had no significant effect on the expression of ZO-1, occludin, collagen IV or aquaporin4 (AQP4). In conclusion, hydrogen gas reduced brain infarction, hemorrhagic transformation, and improved neurological function in rats. The potential mechanisms of decreased oxidative stress and glucose levels after hydrogen treatment warrant further investigation.

Indexed as

Administration, InhalationAldehydesAnimalsAntioxidantsAquaporin 4Brain Damage, ChronicCerebral HemorrhageDisease ProgressionDrug Evaluation, PreclinicalExtracellular Matrix ProteinsGlucoseHydrogenHyperglycemiaInfarction, Middle Cerebral ArteryMaleMatrix Metalloproteinase 23-nitrotyrosine4-hydroxy-2-nonenalAldehydesAntioxidantsAqp4 protein, ratAquaporin 4Extracellular Matrix ProteinsGlucoseHydrogenMatrix Metalloproteinase 2Matrix Metalloproteinase 9Neuroprotective AgentsTyrosine

Identifiers

PMID20423721
PMCPMC2900515
OpenAlexW2004692084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.