ReviewThe Biochemical journal2010
Complexes between photoactivated rhodopsin and transducin: progress and questions.
Review in The Biochemical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Role of VLC-PUFAs in Retinal and Macular Degeneration.Advances in experimental medicine and biology · 2023Article
- Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.Advances in experimental medicine and biology · 2022Review
- Retinoid analogs and polyphenols as potential therapeutics for age-related macular degeneration.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Palmitoylation is a prerequisite for dimerization-dependent raftophilicity of rhodopsin.The Journal of biological chemistry · 2017Article
- Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface.The Journal of biological chemistry · 2015Article
- Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors.Frontiers in pharmacology · 2015Review
- Differential light-induced responses in sectorial inherited retinal degeneration.The Journal of biological chemistry · 2014Article
- Chemistry and biology of the initial steps in vision: the Friedenwald lecture.Investigative ophthalmology & visual science · 2014Article
- Retinal phototransduction.Neurosciences (Riyadh, Saudi Arabia) · 2014Review
- Chemistry of the retinoid (visual) cycle.Chemical reviews · 2014Review
- Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization.The Journal of clinical investigation · 2013Article
- Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models.Progress in retinal and eye research · 2012Review
- Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein.Structure (London, England : 1993) · 2012Article
- Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1).Biochemistry · 2012Article
- Structure and activation of rhodopsin.Acta pharmacologica Sinica · 2012Review
- Signaling states of rhodopsin in rod disk membranes lacking transducin βγ-complex.Investigative ophthalmology & visual science · 2012Article
- G protein-coupled receptors--recent advances.Acta biochimica Polonica · 2012Review
- Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool.PloS one · 2012Article
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin.Biochemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Activation of GPCRs (G-protein-coupled receptors) leads to conformational changes that ultimately initiate signal transduction. Activated GPCRs transiently combine with and activate heterotrimeric G-proteins resulting in GTP replacement of GDP on the G-protein alpha subunit. Both the detailed structural changes essential for productive GDP/GTP exchange on the G-protein alpha subunit and the structure of the GPCR-G-protein complex itself have yet to be elucidated. Nevertheless, transient GPCR-G-protein complexes can be trapped by nucleotide depletion, yielding an empty-nucleotide G-protein-GPCR complex that can be isolated. Whereas early biochemical studies indicated formation of a complex between G-protein and activated receptor only, more recent results suggest that G-protein can bind to pre-activated states of receptor or even couple transiently to non-activated receptor to facilitate rapid responses to stimuli. Efficient and reproducible formation of physiologically relevant, conformationally homogenous GPCR-G-protein complexes is a prerequisite for structural studies designed to address these possibilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.