ReviewInternational journal of hematology2010
Molecular mechanisms underlying deregulation of C/EBPalpha in acute myeloid leukemia.
Review in International journal of hematology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases.Cell discovery · 2026Review
- Synergistic adverse prognosis ofFrontiers in cell and developmental biology · 2026Article
- RNA activation ofMolecular therapy. Nucleic acids · 2025Article
- Review
- Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AML.Clinical and translational medicine · 2020Article
- Transcriptional Regulation ofGenes · 2020Article
- CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity.The Journal of biological chemistry · 2016Article
- Article
- IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα.Experimental and therapeutic medicine · 2016Article
- Hematopoietic myeloid cell differentiation diminishes nucleotide excision repair.International journal of hematology · 2014Article
- C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Initiation of MLL-rearranged AML is dependent on C/EBPα.The Journal of experimental medicine · 2014Article
- Article
- The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.Haematologica · 2013Article
- Article
- Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.Leukemia · 2012Article
- Editorial: granulopoiesis versus monopoiesis: a consequence of transcription factors dancing with the right partners.Journal of leukocyte biology · 2011Article
- Transcriptomic analysis of the zebrafish inner ear points to growth hormone mediated regeneration following acoustic trauma.BMC neuroscience · 2011Article
- Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts.International journal of hematology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CEBPA gene encodes a transcription factor protein that is crucial for granulocytic differentiation, regulation of myeloid gene expression and growth arrest. Mutations in one or both alleles of CEBPA are observed in about 10% of patients with acute myeloid leukemia (AML). Moreover, other genetic events associated with AML have been identified to deregulate C/EBPalpha expression and function at various levels. Recently developed mouse models that accurately mimic the genetic C/EBPalpha alterations in human AML demonstrate C/EBPalpha's gatekeeper function in the control of self-renewal and lineage commitment of hematopoietic stem cells (HSCs). Moreover, these studies indicate that CEBPA mutations affect HSCs in early leukemia development by inducing proliferation and limiting their lineage potential. However, the exact relationship between 'pre-leukemic' HCSs and those cells that finally initiate leukemia (leukemia-initiating cells) with disturbed differentiation and aberrant proliferation remains elusive. More research is needed to identify and characterize these functionally distinct populations and the exact role of the different genetic alterations in the process of leukemia initiation and maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.