ArticleCellular and molecular life sciences : CMLS2010
Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein.
Article in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets.EMBO reports · 2024Article
- The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses.Cellular and molecular life sciences : CMLS · 2022Review
- The Centriolar Adjunct⁻Appearance and Disassembly in Spermiogenesis and the Potential Impact on Fertility.Cells · 2019Article
- Long-term live cells observation of internalized fluorescent Fe@C nanoparticles in constant magnetic field.Journal of nanobiotechnology · 2019Article
- Centrioles without microtubules: a new morphological type of centriole.Biology open · 2018Article
- Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection.Current opinion in cell biology · 2016Review
- Lipid dysregulation in hepatitis C virus, and impact of statin therapy upon clinical outcomes.World journal of gastroenterology · 2015Review
- The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.The Journal of biological chemistry · 2014Article
- Autophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseases.World journal of gastroenterology · 2014Review
- Article
- HIV-1 Nef is transferred from expressing T cells to hepatocytic cells through conduits and enhances HCV replication.PloS one · 2014Article
- Nuclear lipid droplets identified by electron microscopy of serial sections.BMC research notes · 2013Article
- The evolutionarily conserved protein CG9186 is associated with lipid droplets, required for their positioning and for fat storage.Journal of cell science · 2013Article
- Sequential biogenesis of host cell membrane rearrangements induced by hepatitis C virus infection.Cellular and molecular life sciences : CMLS · 2013Article
- Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV core DII protein.PloS one · 2013Article
- Monoubiquitination of ancient ubiquitous protein 1 promotes lipid droplet clustering.PloS one · 2013Article
- Nonstructural 5A protein of hepatitis C virus interacts with pyruvate carboxylase and modulates viral propagation.PloS one · 2013Article
- Viral sequence variation in chronic carriers of hepatitis C virus has a low impact on liver steatosis.PloS one · 2012Article
- Hepatitis C virus assembly imaging.Viruses · 2011Review
- Unique ties between hepatitis C virus replication and intracellular lipids.Trends in endocrinology and metabolism: TEM · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) release is linked to the formation of lipid droplet (LD) clusters in the perinuclear area of infected cells, induced by the core protein. We used electron microscopy (EM) to monitor and compare the number and size of LD in cells producing the mature and immature forms of the HCV core protein, and 3D EM to reconstruct whole cells producing the mature core protein. Only the mature protein coated the LD and induced their clustering and emergence from endoplasmic reticulum membranes enriched in this protein. We found no particular association between LD clusters and the centrosome in reconstructed cells. The LD clustering induced by the mature core protein was associated with an increase in LD synthesis potentially due, at least in part, to the ability of this protein to coat the LD. These observations provide useful information for further studies of the mechanisms involved in HCV-induced steatosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.