ArticlePediatric nephrology (Berlin, Germany)2010
Renal manifestations in children co-infected with HIV and disseminated tuberculosis.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Multidetector computed tomography has replaced conventional intravenous excretory urography in imaging of the kidneys: A scoping review of multidetector computed tomography findings in renal tuberculosis.SA journal of radiology · 2018Article
- Renal transplantation in human immunodeficiency virus (HIV)-positive children.Pediatric nephrology (Berlin, Germany) · 2015Review
- Kidney disease in children and adolescents with perinatal HIV-1 infection.Journal of the International AIDS Society · 2013Review
- Renal tuberculosis in the modern era.The American journal of tropical medicine and hygiene · 2013Review
- The spectrum of HIV-related nephropathy in children.Pediatric nephrology (Berlin, Germany) · 2012Article
- Renal disease in HIV-infected individuals.Current opinion in HIV and AIDS · 2011Review
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many children in Cape Town are co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB). Granulomatous TB interstitial nephritis is a recognized entity. Our objective was to establish if TB plays a role in renal disease in HIV-infected children. We identified children co-infected with TB and HIV from our database and reviewed their biopsies and clinical notes. Since 2002, 12 renal biopsies or postmortem examinations were performed on HIV-infected children at our institution. The clinical scenario and renal biopsies in four cases (median age 73 months, range 24-108 months) were consistent with TB involvement. The mean CD4 count and percentage of these four patients were 508 cells/microl and 23%, respectively. All four patients presented with culture-proven disseminated TB (not yet on treatment) and had nephrotic range proteinuria and hypoalbuminemia. Three of these patients had renal impairment. The prominent features of the renal biopsies were a severe interstitial inflammatory infiltrate and mild to moderate mesangial proliferation. An interstitial granuloma was seen in one patient. With treatment for the TB, the proteinuria resolved and renal function improved in all four patients. Based on these results, we conclude that TB contributes to proteinuric renal disease in HIV-infected children and that the renal disease improves following TB treatment.
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