ArticlePLoS genetics2010
Activation of estrogen-responsive genes does not require their nuclear co-localization.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity.PLoS genetics · 2024Article
- Enhancer-driven 3D chromatin domain folding modulates transcription in human mammary tumor cells.Life science alliance · 2024Article
- Upregulation of an estrogen receptor-regulated gene by first generation progestins requires both the progesterone receptor and estrogen receptor alpha.Frontiers in endocrinology · 2022Article
- Licochalcone A is a Natural Selective Inhibitor of Arginine Methyltransferase 6.The Biochemical journal · 2020Article
- Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH.Journal of visualized experiments : JoVE · 2020Article
- Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity.Nucleic acids research · 2020Article
- The importance of the nuclear positioning of the PPARG gene for its expression during porcine in vitro adipogenesis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2019Article
- Signaling by Steroid Hormones in the 3D Nuclear Space.International journal of molecular sciences · 2018Review
- Real-Time Imaging of a Single Gene Reveals Transcription-Initiated Local Confinement.Biophysical journal · 2017Article
- Large Scale Chromosome Folding Is Stable against Local Changes in Chromatin Structure.PLoS computational biology · 2016Article
- Glucocorticoid receptor and nuclear factor kappa-b affect three-dimensional chromatin organization.Genome biology · 2015Article
- Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.Frontiers in endocrinology · 2015Article
- Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure.Nucleic acids research · 2014Article
- Distinct structural transitions of chromatin topological domains correlate with coordinated hormone-induced gene regulation.Genes & development · 2014Article
- 17β-estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo.International journal of cancer · 2014Article
- Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.Chemistry & biology · 2014Article
- A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function.Biochimica et biophysica acta · 2014Review
- Estrogen induces global reorganization of chromatin structure in human breast cancer cells.PloS one · 2014Article
- H2A.Z-dependent crosstalk between enhancer and promoter regulates cyclin D1 expression.Oncogene · 2013Article
- TIP48/Reptin and H2A.Z requirement for initiating chromatin remodeling in estrogen-activated transcription.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
The spatial organization of the genome in the nucleus plays a role in the regulation of gene expression. Whether co-regulated genes are subject to coordinated repositioning to a shared nuclear space is a matter of considerable interest and debate. We investigated the nuclear organization of estrogen receptor alpha (ERalpha) target genes in human breast epithelial and cancer cell lines, before and after transcriptional activation induced with estradiol. We find that, contrary to another report, the ERalpha target genes TFF1 and GREB1 are distributed in the nucleoplasm with no particular relationship to each other. The nuclear separation between these genes, as well as between the ERalpha target genes PGR and CTSD, was unchanged by hormone addition and transcriptional activation with no evidence for co-localization between alleles. Similarly, while the volume occupied by the chromosomes increased, the relative nuclear position of the respective chromosome territories was unaffected by hormone addition. Our results demonstrate that estradiol-induced ERalpha target genes are not required to co-localize in the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.