ReviewNature reviews. Nephrology2010
Nuclear hormone receptors in diabetic nephropathy.
Review in Nature reviews. Nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Nuclear receptors in metabolic, inflammatory, and oncologic diseases: mechanisms, therapeutic advances, and future directions.European journal of medical research · 2025Review
- The role of the farnesoid X receptor in diabetes and its complications.Molecular and cellular biochemistry · 2025Review
- VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Nuclear receptors in the kidney during health and disease.Molecular aspects of medicine · 2021Review
- Nuclear receptors in podocyte biology and glomerular disease.Nature reviews. Nephrology · 2021Review
- FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake.Journal of translational medicine · 2019Article
- Identification of Transcription Regulatory Relationships in Diabetic Nephropathy.Chinese medical journal · 2018Article
- PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism.Molecular medicine reports · 2018Article
- Exploring Binding Mechanisms in Nuclear Hormone Receptors by Monte Carlo and X-ray-derived Motions.Biophysical journal · 2017Article
- FXR expression is associated with dysregulated glucose and lipid levels in the offspring kidney induced by maternal obesity.Nutrition & metabolism · 2015Article
- Article
- Article
- Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.Clinical science (London, England : 1979) · 2013Review
- Anti-fibrosis therapy and diabetic nephropathy.Current diabetes reports · 2012Review
- Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters.Kidney international · 2011Article
- Kidney aging--inevitable or preventable?Nature reviews. Nephrology · 2011Review
- Pathophysiology of the diabetic kidney.Comprehensive Physiology · 2011Review
- The proximal tubule in the pathophysiology of the diabetic kidney.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Review
- Vitamin D receptor agonist doxercalciferol modulates dietary fat-induced renal disease and renal lipid metabolism.American journal of physiology. Renal physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is the leading cause of end-stage renal disease in developed countries. In spite of glucose and blood pressure control, for example by use of angiotensin II receptor blockers, diabetic nephropathy still develops and progresses in affected patients and the development of additional protective therapeutic interventions is, therefore, required. Nuclear hormone receptors are transcription factors that regulate carbohydrate metabolism, lipid metabolism, the immune response, and inflammation. These receptors also modulate the development of fibrosis. As a result of their diverse biological effects, nuclear hormone receptors have become major pharmaceutical targets for the treatment of a host of diseases. The increasing prevalence of diabetic nephropathy has led intense investigation into the role that nuclear hormone receptors may have in slowing or preventing the progression of renal disease. This role of nuclear hormone receptors would be associated with improvements in metabolism, the immune response, and inflammation. Eight nuclear receptors have shown a renoprotective effect in the context of diabetic nephropathy. This Review discusses the evidence regarding the beneficial effects of the activation of these receptors in preventing the progression of diabetic nephropathy and describes how the discovery and development of compounds that modulate the activity of nuclear hormone receptors may provide potential additional therapeutic approaches in the management of diabetic nephropathy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.