Evidence map›Paper›PMID 20421872›Full record

ReviewNature reviews. Genetics2010

Inducible gene expression: diverse regulatory mechanisms.

Vikki M Weake, Jerry L Workman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 374 citations in OpenAlex.

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  20. The advent of plant cells in bioreactors.Frontiers in plant science · 2023
    Review

136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vikki M WeakeStowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Jerry L Workman
Stowers Institute for Medical Research · US

Funding

Analysis of metazoan SAGA complex function in gene expressionR01GM099945 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ABMAYR, SUSAN M, WORKMAN, JERRY L · 2012 to 2015
$1.2M
NIGMS NIH HHS R01 GM099945
6 · The paper itself

Abstract

The rapid activation of gene expression in response to stimuli occurs largely through the regulation of RNA polymerase II-dependent transcription. In this Review, we discuss events that occur during the transcription cycle in eukaryotes that are important for the rapid and specific activation of gene expression in response to external stimuli. In addition to regulated recruitment of the transcription machinery to the promoter, it has now been shown that control steps can include chromatin remodelling and the release of paused polymerase. Recent work suggests that some components of signal transduction cascades also play an integral part in activating transcription at target genes.

Indexed as

AnimalsChromatin Assembly and DisassemblyGene Regulatory NetworksHumansModels, BiologicalPhosphotransferasesSignal TransductionTranscriptional ActivationTranscription FactorsTranscription, GeneticPhosphotransferasesTranscription Factors

Identifiers

PMID20421872
OpenAlexW2167241965

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.