ArticlePsychiatric genetics2010
Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR).
Article in Psychiatric genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population.Genes & nutrition · 2018Article
- Sex differences modulating serotonergic polymorphisms implicated in the mechanistic pathways of risk for depression and related disorders.Journal of neuroscience research · 2017Review
- Genes in the dopaminergic system and delinquent behaviors across the life course: the role of social controls and risks.Criminal justice and behavior · 2014Article
- Genetic influences on adolescent sexual behavior: Why genes matter for environmentally oriented researchers.Psychological bulletin · 2014Review
- Serotonin Transporter Genotype Linked to Adolescent Substance Use Treatment Outcome through Externalizing Behavior.Frontiers in pediatrics · 2014Article
- Bringing a developmental perspective to anxiety genetics.Development and psychopathology · 2012Review
- A latent modeling approach to genotype-phenotype relationships: maternal problem behavior clusters, prenatal smoking, and MAOA genotype.Archives of women's mental health · 2012Article
- Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster.Behavior genetics · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundConduct disorder is a serious, relatively common disorder of childhood and adolescence. Findings from genetic association studies searching for genetic determinants of the liability toward such behaviors have been inconsistent. One possible explanation for differential results is that most studies define phenotype from a single assessment; for many adolescents conduct problems decrease in severity over time, whereas for others such behaviors persist. Therefore, longitudinal datasets offer the opportunity to refine phenotype.
methodsWe used Caucasians that were first assessed during adolescence from the National Youth Survey Family Study. Nine waves of data were used to create latent growth trajectories and test for associations between trajectory class and 5HTTLPR genotype.
resultsFor the full sample, 5HTTLPR was not associated with conduct problem phenotypes. However, the short (s) allele was associated with chronic conduct problems in females; a nominally significant sex by 5HTTLPR genotype interaction was noted.
conclusionLongitudinal studies provide unique opportunities for phenotypic refinement and such techniques, with large samples, may be useful for phenotypic definition with other study designs, such as whole genome association studies.
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