ArticleProceedings of the National Academy of Sciences of the United States of America2010
Global characteristics of protein sequences and their implications.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Machine Learning Approaches for Interpretable Antibody Property Prediction Using Structural Data.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Rapid discrimination between deleterious and benign missense mutations in the CAGI 6 experiment.Human genomics · 2024Article
- The structure of protein dynamic space.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- CXCR3 Identifies Human Naive CD8Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Sequence-specific dynamic information in proteins.Proteins · 2019Article
- Memory CD4Nature immunology · 2019Article
- Numerical Encodings of Amino Acids in Multivariate Gaussian Modeling of Protein Multiple Sequence Alignments.Molecules (Basel, Switzerland) · 2018Article
- Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors.Frontiers in immunology · 2018Article
- Global informatics and physical property selection in protein sequences.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Nonlinearities in protein space limit the utility of informatics in protein biophysics.Proteins · 2015Article
- 3D representations of amino acids-applications to protein sequence comparison and classification.Computational and structural biotechnology journal · 2014Article
- Homolog detection using global sequence properties suggests an alternate view of structural encoding in protein sequences.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- An improved sequence based prediction protocol for DNA-binding proteins using SVM and comprehensive feature analysis.BMC bioinformatics · 2013Article
- Prediction of functionally important residues in globular proteins from unusual central distances of amino acids.BMC structural biology · 2011Article
- Distribution and cluster analysis of predicted intrinsically disordered protein Pfam domains.Intrinsically disordered proteinsArticle
Corrections and comments
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Authors and funding
1 author.
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Abstract
Computational studies of the relationships between protein sequence, structure, and folding have traditionally relied on purely local sequence representations. Here we show that global representations, on the basis of parameters that encode information about complete sequences, contain otherwise inaccessible information about the organization of sequences. By studying the spectral properties of these parameters, we demonstrate that amino acid physical properties fall into two distinct classes. One class is comprised of properties that favor sequentially localized interaction clusters. The other class is comprised of properties that favor globally distributed interactions. This observation provides a bridge between two classic models of protein folding-the collapse model and the nucleation model-and provides a basis for understanding how any degree of intermediacy between these two extremes can occur.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.