ArticleProceedings of the National Academy of Sciences of the United States of America2010
Nitrosopumilus maritimus genome reveals unique mechanisms for nitrification and autotrophy in globally distributed marine crenarchaea.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 350 papers.
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Who cites it
350 citing papers in PubMed, 933 citations in OpenAlex.
- Hypoxia and acidification antagonistically suppress nitrification but enhance its NScience advances · 2026Article
- Ecological significance of dark carbon fixation driven by ammonia oxidation in estuarine waters.Eco-Environment & Health · 2026Article
- Oxygen production as an electron overflow pathway in ammonia-oxidizing archaea.Science advances · 2026Article
- Ammonia monooxygenase: a work in progress.Chemical science · 2026Review
- Copper requirements and copper toxicity as niche-defining factors in the growth of terrestrial ammonia-oxidizing archaea and bacteria.FEMS microbiology ecology · 2026Article
- Ocean warming enhances iron use efficiencies of marine ammonia-oxidizing archaea.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hydrazine Synthase From Anammox Is Inhibited by Linear and Aromatic Alkynes.Environmental microbiology · 2026Article
- A novel North Sea ammonia-oxidizing archaeon Nitrosarchaeum marinum leverages a high abundance of transport systems to grow over a wide salinity range.FEMS microbiology ecology · 2026Article
- Elevated temperature simulating heatwaves restructures active nitrifying communities and associated viruses in tidal flats and agricultural soils.The ISME journal · 2026Article
- Distinct patterns of microbial association across deep-sea corals from the Western Pacific Magellan Seamounts.Microbiology spectrum · 2026Article
- Dynamics and Eco-Genomics of Baltic Sea Nitrifiers: Seasonality, Niches, Interactions and Genomic Uniqueness.Environmental microbiology · 2026Article
- The hidden potential of archaea in carbon and nitrogen cycling in agricultural soils: a review.Frontiers in microbiology · 2026Review
- Niche adaptation of particle-associated ammonia-oxidizing archaea sustains nitrification under marine deoxygenation.Frontiers in microbiology · 2026Article
- Urea use drives niche separation between dominant marine ammonia oxidizing archaea.Nature communications · 2025Article
- Multi-Habitat Landscape Promotes Microbial Diversity: Insights from the Traditional Agricultural Heritage and the Global Trend.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Article
- Exploring the interactions between algae and archaea.Marine life science & technology · 2025Review
- The Ammonia Oxidising Archaeon Nitrosopumilus maritimus Does Not Alter Iodine Oxidation State in Oxic Seawater.Environmental microbiology reports · 2025Article
- Exploring proteinmBio · 2025Article
- Nitrosarchaeum haohaiensis sp. Nov. CL1Environmental microbiology reports · 2025Article
290 more citing papers are in PubMed but not listed here.
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Authors and funding
24 authors at 14 institutions in 3 countries.
Funding
Abstract
Ammonia-oxidizing archaea are ubiquitous in marine and terrestrial environments and now thought to be significant contributors to carbon and nitrogen cycling. The isolation of Candidatus "Nitrosopumilus maritimus" strain SCM1 provided the opportunity for linking its chemolithotrophic physiology with a genomic inventory of the globally distributed archaea. Here we report the 1,645,259-bp closed genome of strain SCM1, revealing highly copper-dependent systems for ammonia oxidation and electron transport that are distinctly different from known ammonia-oxidizing bacteria. Consistent with in situ isotopic studies of marine archaea, the genome sequence indicates N. maritimus grows autotrophically using a variant of the 3-hydroxypropionate/4-hydroxybutryrate pathway for carbon assimilation, while maintaining limited capacity for assimilation of organic carbon. This unique instance of archaeal biosynthesis of the osmoprotectant ectoine and an unprecedented enrichment of multicopper oxidases, thioredoxin-like proteins, and transcriptional regulators points to an organism responsive to environmental cues and adapted to handling reactive copper and nitrogen species that likely derive from its distinctive biochemistry. The conservation of N. maritimus gene content and organization within marine metagenomes indicates that the unique physiology of these specialized oligophiles may play a significant role in the biogeochemical cycles of carbon and nitrogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.