ArticleThe Journal of biological chemistry2010
Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The Phospholipase AJournal of lipid and atherosclerosis · 2026Review
- Bmal1 regulates female reproduction in mice via the hypothalamic-pituitary-ovarian axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Secretory Phospholipase A2s in Insulin Resistance and Metabolism.Frontiers in endocrinology · 2021Review
- Metabolic regulation by secreted phospholipase AInflammation and regeneration · 2016Review
- A new era of secreted phospholipase A₂.Journal of lipid research · 2015Article
- Ectopically expressed pro-group X secretory phospholipase A2 is proteolytically activated in mouse adrenal cells by furin-like proprotein convertases: implications for the regulation of adrenal steroidogenesis.The Journal of biological chemistry · 2015Article
- Modulation of adrenocorticotrophin hormone (ACTH)-induced expression of stress-related genes by PUFA in inter-renal cells from European sea bass (Dicentrarchus labrax).Journal of nutritional science · 2015Article
- Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.The Journal of biological chemistry · 2014Article
- Group X secreted phospholipase A(2) induces lipid droplet formation and prolongs breast cancer cell survival.Molecular cancer · 2013Article
- Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle.Genetics · 2012Article
- Group X secretory phospholipase A2 enhances TLR4 signaling in macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.The Journal of biological chemistry · 2011Article
- Hair follicular expression and function of group X secreted phospholipase A2 in mouse skin.The Journal of biological chemistry · 2011Article
- Integrated lipidomics in the secreted phospholipase A(2) biology.International journal of molecular sciences · 2011Review
- Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We developed C57BL/6 mice with targeted deletion of group X secretory phospholipase A(2) (GX KO). These mice have approximately 80% higher plasma corticosterone concentrations compared with wild-type (WT) mice under both basal and adrenocorticotropic hormone (ACTH)-induced stress conditions. This increased corticosterone level was not associated with increased circulating ACTH or a defect in the hypothalamic-pituitary axis as evidenced by a normal response to dexamethasone challenge. Primary cultures of adrenal cells from GX KO mice exhibited significantly increased corticosteroid secretion compared with WT cells. Conversely, overexpression of GX secretory phospholipase A(2) (sPLA(2)), but not a catalytically inactive mutant form of GX sPLA(2), significantly reduced steroid production 30-40% in Y1 mouse adrenal cell line. This effect was reversed by the sPLA(2) inhibitor, indoxam. Silencing of endogenous M-type receptor expression did not restore steroid production in GX sPLA(2)-overexpressing Y1 cells, ruling out a role for this sPLA(2) receptor in this regulatory process. Expression of steroidogenic acute regulatory protein (StAR), the rate-limiting protein in corticosteroid production, was approximately 2-fold higher in adrenal glands of GX KO mice compared with WT mice, whereas StAR expression was suppressed in Y1 cells overexpressing GX sPLA(2). Results from StAR-promoter luciferase reporter gene assays indicated that GX sPLA(2) antagonizes StAR promoter activity and liver X receptor-mediated StAR promoter activation. In summary, GX sPLA(2) is expressed in mouse adrenal glands and functions to negatively regulate corticosteroid synthesis, most likely by negatively regulating StAR expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.