ArticleThe Journal of biological chemistry2010
HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- HDAC11 Regulates RNA Splicing via De-Fatty Acylation of SF3B2.bioRxiv : the preprint server for biology · 2026Article
- DNA methylation and lipid metabolism are involved in GA-induced maize aleurone layers PCD as revealed by transcriptome analysis.BMC plant biology · 2023Article
- Biological functions and research progress of eIF4E.Frontiers in oncology · 2023Review
- Uncover New Reactivity of Genetically Encoded Alkyl Bromide Non-Canonical Amino Acids.Frontiers in chemistry · 2022Article
- Regulation of the mammalian maternal-to-embryonic transition by eukaryotic translation initiation factor 4E.Development (Cambridge, England) · 2021Article
- A deep analysis of the proteomic and phosphoproteomic alterations that occur in skeletal muscle after the onset of immobilization.The Journal of physiology · 2021Article
- Article
- Low-concentration DMSO accelerates skin wound healing by Akt/mTOR-mediated cell proliferation and migration in diabetic mice.British journal of pharmacology · 2020Article
- MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation.Cell death and differentiation · 2019Article
- Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells.Cell death & disease · 2018Article
- Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation.Scientific reports · 2017Article
- The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency.Cell reports · 2017Article
- A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation.Scientific reports · 2017Article
- Fusion proteins ofTranslation (Austin, Tex.) · 2016Article
- Class I and IIa histone deacetylases have opposite effects on sclerostin gene regulation.The Journal of biological chemistry · 2014Article
- Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation.Translation (Austin, Tex.) · 2014Review
- The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.PloS one · 2014Article
- Article
- DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.The Journal of biological chemistry · 2013Article
- Diversity of Eukaryotic Translational Initiation Factor eIF4E in Protists.Comparative and functional genomics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deacetylase activity. By stimulating eIF4E sumoylation, HDAC2 induces the formation of the active eukaryotic initiation factor 4F (eIF4F) complex and induces the protein synthesis of a subset of eIF4E-responsive genes that are essential for cell proliferation and preventing apoptosis. These data demonstrate that HDAC2 has an unexpected sumoylation-promoting activity and regulates cap-dependent mRNA translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.