ArticleJournal of the American College of Surgeons2010
Diagnosis-dependent relationships between cytokine levels and survival in patients admitted for surgical critical care.
Article in Journal of the American College of Surgeons, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Clinical review: Statins and trauma--a systematic review.Critical care (London, England) · 2013Pooled it
- [Changes in the tumor necrosis factor-α level after an ultrasound-guided femoral nerve block in elderly patients with a hip fracture].Brazilian journal of anesthesiology (Elsevier)Trial
- Dynamics of immune responses are inconsistent when trauma patients are grouped by injury severity score and clinical outcomes.Scientific reports · 2023Article
- Article
- Therapeutic Potential of Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Prevention of Organ Injuries Induced by Traumatic Hemorrhagic Shock.Frontiers in immunology · 2021Review
- Combination Preemptive Peripheral Nerve Block in Limb Surgery. A Prospective Study.Medicina (Kaunas, Lithuania) · 2020Article
- Cardiac troponin T is associated with mortality in patients admitted to critical care in a UK major trauma centre: a retrospective database analysis.Journal of the Intensive Care Society · 2019Article
- Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock.Frontiers in immunology · 2019Article
- Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries in the early period after trauma.Central-European journal of immunology · 2018Article
- An FcγRIIa polymorphism with decreased C-reactive protein binding is associated with sepsis and decreased monocyte HLA-DR expression in trauma patients.The journal of trauma and acute care surgery · 2015Observational
- Inflammatory mediators in intra-abdominal sepsis or injury - a scoping review.Critical care (London, England) · 2015Article
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- A Study of Inflammatory/Necrosis Biomarkers in the Fracture of the Femur Treated with Proximal Femoral Nail Antirotation.Mediators of inflammation · 2015Article
- Sex- and diagnosis-dependent differences in mortality and admission cytokine levels among patients admitted for intensive care.Critical care medicine · 2014Observational
- Changes in serum cytokines in response to musculoskeletal surgical trauma.BMC research notes · 2014Article
- Severe traumatic head injury affects systemic cytokine expression.Journal of the American College of Surgeons · 2012Article
- Data driven linear algebraic methods for analysis of molecular pathways: application to disease progression in shock/trauma.Journal of biomedical informatics · 2012Article
- Granulicatella adiacens bacteremia in an elderly trauma patient.Surgical infections · 2011Article
- Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients.Critical care (London, England) · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeath after trauma, infection, or other critical illness has been attributed to unbalanced inflammation, in which dysregulation of cytokines leads to multiple organ dysfunction and death. We hypothesized that admission cytokine profiles associated with death would differ based on admitting diagnosis. STUDY
designThis 5-year study included patients admitted for trauma or surgical intensive care for more than 48 hours at 2 academic, tertiary care hospitals between October 2001 and May 2006. Cytokine analysis for interleukin (IL)-1, -2, -4, -6, -8, -10, -12, interferon-gamma, and tumor necrosis factor (TNF)-alpha was performed using ELISA on specimens drawn within 72 hours of admission. Mann-Whitney U test was used to compare median admission cytokine levels between alive and deceased patients. Relative risks and odds of death associated with admission cytokines were generated using univariate analysis and multivariate logistic regression models, respectively.
resultsThere were 1,655 patients who had complete cytokine data: 290 infected, nontrauma; 343 noninfected, nontrauma; and 1,022 trauma. Among infected patients, nonsurvivors had higher median admission levels of IL-2, -8, -10, and granulocyte macrophage-colony stimulating factor; noninfected, nontrauma patients had higher IL-6, -8, and IL-10; and nonsurviving trauma patients had higher IL-4, -6, -8, and TNF-alpha. IL-4 was the most significant predictor of death and carried the highest relative risk of dying in trauma patients, and IL-8 in nontrauma, noninfected patients. In infected patients, no cytokine independently predicted death.
conclusionsCytokine profiles of certain disease states may identify persons at risk of dying and allow for selective targeting of multiple cytokines to prevent organ dysfunction and death.
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