ArticleExperimental cell research2010
Cell density-dependent transcriptional activation of endocrine-related genes in human adipose tissue-derived stem cells.
Article in Experimental cell research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Toward Efficient Beige Adipogenesis: Protocol Optimization Using Adipose-Derived Stem Cells.Cells · 2025Article
- Activation of central and peripheral transient receptor potential melastatin 8 increases susceptibility to spreading depolarization and facilitates trigeminal neuroinflammation.The journal of headache and pain · 2025Article
- Lipedema: A Disease Triggered by M2 Polarized Macrophages?Biomedicines · 2025Review
- Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone.Molecular and cellular endocrinology · 2024Article
- SIX1+PAX3+ identify a progenitor for myogenic lineage commitment from hPSCs.Development (Cambridge, England) · 2023Article
- The DevTox Germ Layer Reporter Platform: An Assay Adaptation of the Human Pluripotent Stem Cell Test.Toxics · 2022Article
- Suprabasin-A Review.Genes · 2021Review
- Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation.Stem cell research & therapy · 2021Review
- A method for differentiating human induced pluripotent stem cells toward functional cardiomyocytes in 96-well microplates.Scientific reports · 2020Article
- The use of autologous fat grafts in breast surgery: A literature review.Archives of plastic surgery · 2019Article
- PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.Nature communications · 2019Article
- Controlling fluid flow to improve cell seeding uniformity.PloS one · 2018Article
- Article
- Steroid Androgen Exposure during Development Has No Effect on Reproductive Physiology of Biomphalaria glabrata.PloS one · 2016Article
- Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem Cells.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Association of obesity and circulating adipose stromal cells among breast cancer survivors.Molecular biology reports · 2014Article
- Adult adipose-derived stem cells and breast cancer: a controversial relationship.SpringerPlus · 2014Review
- Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells.PloS one · 2013Article
- Current methods of adipogenic differentiation of mesenchymal stem cells.Stem cells and development · 2011Review
- Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Adipose tissue is recognized as an endocrine organ that plays an important role in human diseases such as type II diabetes and cancer. Human adipose tissue-derived stem cells (ASCs), a distinct cell population in adipose tissue, are capable of differentiating into multiple lineages including adipogenesis. When cultured in vitro under a confluent condition, ASCs reach a commitment stage for adipogenesis, which can be further induced into terminally differentiated adipocytes by a cocktail of adipogenic factors. Here we report that the confluent state of ASCs triggers transcriptional activation cascades for genes that are responsible for the endocrine function of adipose tissue. These include insulin-like growth factor 1 (IGF-1) and aromatase (Cyp19), a key enzyme in estrogen biosynthesis. Despite similar adipogenic potentials, ASCs from different individuals display huge variations in activation of these endocrine-related genes. Bioinformatics and experimental data suggest that transcription factor Foxo1 controls a large number of "early" confluency-response genes, which subsequently induce "late" response genes. Furthermore, siRNA-mediated knockdown of Foxo1 substantially compromises the ability of committed ASCs to stimulate tumor cell migration in vitro. Thus, our work suggests that cell density is an important determinant of the endocrine potential of ASCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.