Evidence map›Paper›PMID 20420525›Full record

ReviewAnnual review of nutrition2010

Evolutionary adaptations to dietary changes.

F Luca, G H Perry, A Di Rienzo

Abstract readReview
In one paragraph

Review in Annual review of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 3 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 250 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Influence of food patterns on endothelial biomarkers: a systematic review.Journal of clinical hypertension (Greenwich, Conn.) · 2014
    Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Increased abundance of Limosilactobacillus reuteri in the gut of selectively bred high-tameness mice and its association with behavioural changes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  10. Review
  11. Review
  12. Review
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  17. Zeaxanthin augments CD8Cell reports. Medicine · 2025
    Article
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

F LucaDepartment of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA. fluca@bsd.uchicago.edu
G H Perry
A Di Rienzo
University of Chicago · US

Funding

POPULATION AND EVOLUTIONARY GENETICS OF NIDDMIR01DK056670 · NIDDK · UNIVERSITY OF CHICAGO · PI DI RIENZO, ANNA · 2001 to 2010
$3.2M
Local Adaptations in HumansR01GM079558 · NIGMS · UNIVERSITY OF CHICAGO · PI DI RIENZO, ANNA · 2007 to 2010
$1.2M
Studying the evolution of gene regulation at the protein level in primatesF32GM085998 · NIGMS · UNIVERSITY OF CHICAGO · PI PERRY, GEORGE HERBERT · 2008 to 2010
$143k
NIDDK NIH HHS DK56670NIDDK NIH HHS R01 DK056670NIGMS NIH HHS F32 GM085998NIGMS NIH HHS GM79558NIGMS NIH HHS R01 GM079558
6 · The paper itself

Abstract

Through cultural innovation and changes in habitat and ecology, there have been a number of major dietary shifts in human evolution, including meat eating, cooking, and those associated with plant and animal domestication. The identification of signatures of adaptations to such dietary changes in the genome of extant primates (including humans) may shed light not only on the evolutionary history of our species, but also on the mechanisms that underlie common metabolic diseases in modern human populations. In this review, we provide a brief overview of the major dietary shifts that occurred during hominin evolution, and we discuss the methods and approaches used to identify signals of natural selection in patterns of sequence variation. We then review the results of studies aimed at detecting the genetic loci that played a major role in dietary adaptations and conclude by outlining the potential of future studies in this area.

Indexed as

Biological EvolutionDietAdaptation, PhysiologicalAnimalsCultureEcosystemGenetic VariationGenomeHominidaeHumansNutritional Physiological PhenomenaSelection, Genetic

Identifiers

PMID20420525
PMCPMC4163920
OpenAlexW2168912387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.