Evidence map›Paper›PMID 20419838›Full record

ArticleWorld journal of gastroenterology2010

Distribution of different hepatitis C virus genotypes in patients with hepatitis C virus infection.

Farah Bokharaei Salim, Hossein Keyvani, Afsaneh Amiri, Fatemeh Jahanbakhsh Sefidi, Ramin Shakeri, Farhad Zamani

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Epidemiology of hepatitis C virus in Iran.World journal of gastroenterology · 2015
    Review
  7. Review
  8. Article
  9. Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Farah Bokharaei SalimGI and Liver Disease Research Centre, Iran University of Medical Sciences, Firouzgar Hospital, Valadi Street, Valiasr Square, Tehran, Iran.
Hossein Keyvani
Afsaneh Amiri
Fatemeh Jahanbakhsh Sefidi
Ramin Shakeri
Farhad Zamani
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the presence of mixed infection and discrepancy between hepatitis C virus (HCV) genotypes in plasma, peripheral blood mononuclear cells (PBMCs), and liver biopsy specimens.

methodsFrom September 2008 up to April 2009, 133 patients with chronic hepatitis C referred to Firouzgar Hospital for initiation of an antiviral therapy were recruited in the study. Five milliliters of peripheral blood was collected from each patient and liver biopsy was performed in those who gave consent or had indications. HCV genotyping was done using INNO-LiPA(TM) HCV II in serum, PBMCs, and liver biopsy specimens and then confirmed by sequencing of 5'-UTR fragments.

resultsThe mean age of patients was 30.3 +/- 17.1 years. Multiple transfusion was seen in 124 (93.2%) of patients. Multiple HCV genotypes were found in 3 (2.3%) of 133 plasma samples, 9 (6.8%) of 133 PBMC samples, and 8 (18.2%) of 44 liver biopsy specimens. It is notable that the different genotypes found in PBMCs were not the same as those found in plasma and liver biopsy specimens.

conclusionOur study shows that a significant proportion of patients with chronic hepatitis C are affected by multiple HCV genotypes which may not be detectable only in serum of patients.

Indexed as

Genotype5' Untranslated RegionsAdultBiopsyCross-Sectional StudiesFemaleGenes, ViralHepacivirusHepatitis CHumansLeukocytes, MononuclearLiverMaleMiddle AgedRNA, Viral5' Untranslated RegionsRNA, Viral

Identifiers

PMID20419838
PMCPMC2860078
OpenAlexW2152378011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.