ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A multilayered stress-response circuit: The mammalian mitochondrial UPR.The FEBS journal · 2026Review
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis.PLoS genetics · 2024Article
- Mitochondrial unfolded protein response (UPRFrontiers in cell and developmental biology · 2024Review
- DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones.Nature communications · 2023Article
- The UPRmt preserves mitochondrial import to extend lifespan.The Journal of cell biology · 2022Article
- Natural Bioactive Products and Alzheimer's Disease Pathology: Lessons fromDiseases (Basel, Switzerland) · 2022Review
- Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration.Aging cell · 2022Review
- Lifespan Extension ofInternational journal of molecular sciences · 2022Article
- Novel putative interactors of FZO-1/mitofusin 2 identified using large-scale yeast two-hybrid screening inmicroPublication biology · 2022Article
- Betulinic acid increases lifespan and stress resistanceFrontiers in nutrition · 2022Article
- Effects of Pesticides on Longevity and Bioenergetics in Invertebrates-The Impact of Polyphenolic Metabolites.International journal of molecular sciences · 2021Article
- High-Dose Irradiation Inhibits Motility and Induces Autophagy inInternational journal of molecular sciences · 2021Article
- Roles of mitochondrial unfolded protein response in mammalian stem cells.World journal of stem cells · 2021Review
- Systemic regulation of mitochondria by germline proteostasis prevents protein aggregation in the soma ofScience advances · 2021Article
- Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases.Frontiers in pharmacology · 2018Review
- Cell Biology of the Mitochondrion.Genetics · 2017Review
- Article
- FAH domain containing protein 1 (FAHD-1) is required for mitochondrial function and locomotion activity in C. elegans.PloS one · 2015Article
- Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome.Cellular and molecular life sciences : CMLS · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
The protein quality control system, composed of molecular chaperones and proteases, is of vital importance for the maintenance and function of the proteome and the health of the cell. To achieve this, the cellular proteostasis network integrates the protein folding machinery across all compartments of the eukaryotic cell to enable efficient communication and coordinate a rapid response of folding capacity. Quality control in the mitochondria, however, differs from its cytosolic counterpart due to its prokaryotic origin, and is entirely encoded by the nuclear genome. The control and regulatory cross-talk of mitochondrial function in cellular proteostasis is essential for cellular metabolism, organismal development, and lifespan. Consequently, mitochondrial dysfunction has dramatic effects on the development and progression of a number of neurodegenerative diseases, such as Friedreich's ataxia and Parkinson's disease. Studies using Caenorhabditis elegans as a model system have greatly contributed to our current knowledge of inter-compartmental proteostasis on the cellular and organismal levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.