ReviewDevelopmental disabilities research reviews2010
Anomalous development of brain structure and function in spina bifida myelomeningocele.
Review in Developmental disabilities research reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review.Neuroradiology · 2022Pooled it
- Academic achievement and needs of school-aged children born with selected congenital anomalies: A systematic review and meta-analysis.Birth defects research · 2021Pooled it
- Cranial findings detected by second-trimester ultrasound in fetuses with myelomeningocele: a systematic review.BJOG : an international journal of obstetrics and gynaecology · 2021Pooled it
- Are Shunt Revisions Associated with IQ in Congenital Hydrocephalus? A Meta -Analysis.Neuropsychology review · 2016Pooled it
- Interhemispheric fissure distortion in fetal open spina bifida: an under-recognized prenatal ultrasound finding.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Article
- Chiari II brain malformation is secondary to open spina bifida.Disease models & mechanisms · 2026Article
- Prevalence of epilepsy and structural brain anomalies in spina bifida aperta.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Long-term cognitive outcomes of Chiari II malformation and corpus callosum abnormalities in myelomeningocele.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Cranial magnetic resonance imaging findings in 167 patients with spina bifida aperta: a retrospective study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Review
- Variation in Neurodegeneration-Linked Brain Regions in Young Adult APOE E4 Carriers With Spina Bifida.Annals of the Child Neurology Society · 2025Article
- Differences in brain development and need for CSF diversion based on MMC level: Comparison between prenatal and postnatal repair.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Memory in Spina Bifida, from Childhood to Adulthood: A Systematic Review.Journal of clinical medicine · 2024Review
- Effect of cervical and lumbosacral spina bifida cystica on volumes of intracranial structures in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Thalamic connectivity topography in newborns with spina bifida: association with neurological functional level but not developmental outcome at 2 years.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Assessment of longitudinal brain development using super-resolution magnetic resonance imaging following fetal surgery for open spina bifida.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2023Article
- Article
- The Role of Fetal Brain Magnetic Resonance Imaging in Current Fetal Medicine.Journal of the Belgian Society of Radiology · 2022Article
- Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study.Neuroradiology · 2021Article
- Cognitive function and performance of everyday activities in adults with spina bifida.Journal of rehabilitation medicine · 2021Article
- Assessment of Health Literacy and Self-reported Readiness for Transition to Adult Care Among Adolescents and Young Adults With Spina Bifida.JAMA network open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Spina bifida myelomeningocele (SBM) is a specific type of neural tube defect whereby the open neural tube at the level of the spinal cord alters brain development during early stages of gestation. Some structural anomalies are virtually unique to individuals with SBM, including a complex pattern of cerebellar dysplasia known as the Chiari II malformation. Other structural anomalies are not necessarily unique to SBM, including altered development of the corpus callosum and posterior fossa. Within SBM, tremendous heterogeneity is reflected in the degree to which brain structures are atypical in qualitative appearance and quantitative measures of morphometry. Hallmark structural features of SBM include overall reductions in posterior fossa and cerebellum size and volume. Studies of the corpus callosum have shown complex patterns of agenesis or hypoplasia along its rostral-caudal axis, with rostrum and splenium regions particularly susceptible to agenesis. Studies of cortical regions have demonstrated complex patterns of thickening, thinning, and gyrification. Diffusion tensor imaging studies have reported compromised integrity of some specific white matter pathways. Given equally complex ocular motor, motor, and cognitive phenotypes consisting of relative strengths and weaknesses that seem to align with altered structural development, studies of SBM provide new insights to our current understanding of brain structure-function associations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.