ArticleMethods in molecular biology (Clifton, N.J.)2010
Glucose transporters in parasitic protozoa.
Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Pathogenic Protist Transmembranome database (PPTdb): a web-based platform for searching and analysis of protist transmembrane proteins.BMC bioinformatics · 2019Article
- The superfamily keeps growing: Identification in trypanosomatids of RibJ, the first riboflavin transporter family in protists.PLoS neglected tropical diseases · 2017Article
- Purification and Characterization of a Novel Intracellular Sucrase Enzyme of Leishmania donovani Promastigotes.Biochemistry research international · 2016Article
- Sugar activation and glycosylation in Plasmodium.Malaria journal · 2015Review
- Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis.International journal for parasitology · 2015Article
- Why do malaria parasites increase host erythrocyte permeability?Trends in parasitology · 2014Review
- Transport proteins of parasitic protists and their role in nutrient salvage.Frontiers in plant science · 2014Review
- Nutrient transport and pathogenesis in selected parasitic protozoa.Eukaryotic cell · 2011Review
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1 author at 1 institution in 1 country.
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Abstract
Glucose and related hexoses play central roles in the biochemistry and metabolism of single-cell parasites such as Leishmania, Trypanosoma, and Plasmodium that are the causative agents of leishmaniasis, African sleeping sickness, and malaria. Glucose transporters and the genes that encode them have been identified in each of these parasites and their functional properties have been scrutinized. These transporters are related in sequence and structure to mammalian facilitative glucose transporters of the SLC2 family, but they are nonetheless quite divergent in sequence. Hexose transporters have been shown to be essential for the viability of the infectious stage of each of these parasites and thus may represent targets for development of novel anti-parasitic drugs. The study of these transporters also illuminates many aspects of the basic biology of Leishmania, trypanosomes, and malaria parasites.
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