ReviewQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2010
Which patient will feel down, which will be happy? The need to study the genetic disposition of emotional states.
Review in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.PloS one · 2018Trial
- Narrative meaning making and integration: Toward a better understanding of the way falling ill influences quality of life.Journal of health psychology · 2020Article
- The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Genetic variations underlying self-reported physical functioning: a review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Review
- How recent health-related life events affected my perspective on quality-of-life research.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
- Article
- Biological pathways, candidate genes, and molecular markers associated with quality-of-life domains: an update.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014Review
- Psychosocial determinants of mental health and risk behaviours in adolescents.Global journal of health science · 2014Article
- Biological pathways and genetic mechanisms involved in social functioning.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2013Article
- Genetic and environmental multidimensionality of well- and ill-being in middle aged twin men.Behavior genetics · 2012Article
- Genetic variations and patient-reported quality of life among patients with lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Article
- Biomarkers: symptoms, survivorship, and quality of life.Seminars in oncology nursing · 2012Review
- Cancer-related fatigue: epidemiology, pathogenesis, diagnosis, and treatment.Deutsches Arzteblatt international · 2012Article
- Article
- Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2010Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn quality-of-life (QL) research, the genetic susceptibility of negative and positive emotions is frequently ignored, taken for granted, or treated as noise. The objectives are to describe: (1) the major findings of studies addressing the heritable and environmental causes of variation in negative and positive emotional states and (2) the major biological pathways of and genetic variants involved in these emotional states.
methodsLiterature overview.
resultsThe heritability estimates for anxiety and depression are 30-40%. Related traits as neuroticism and loneliness are also highly heritable. The hypothalamo-pituitary-adrenal axis is the 'final common pathway' for most depressive symptoms. The many findings of investigated genes are promising but not definitive. Heritability estimates of positive emotional states range between 40 and 50%. Life satisfaction and mental health share common genetic factors with optimism and self-esteem. The prefrontal cortex is a candidate brain area for positive emotional states. Biological and genetic research into positive emotional states is scarce.
conclusionGenetically informative studies may provide insights into a wide variety of complex questions that traditional QL studies cannot deliver. This insight in turn will help us to design more effective supportive programs that could moderate the outcomes of genetically based predispositions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.