Evidence map›Paper›PMID 20419352›Full record

ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2010

Blue moon neurovirology: the merits of studying rare CNS diseases of viral origin.

Lauren A O'Donnell, Glenn F Rall

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 18 citations in OpenAlex.

  1. Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2021
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
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  8. CD4Virology · 2016
    Article
  9. Review
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  11. Article
  12. Review
  13. Review
  14. Article
  15. HCV: Written in our DNA.Self/nonself · 2011
    Article
  16. Viral infections of the central nervous system: pathogenesis to therapeutics.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lauren A O'DonnellProgram in Immune Cell Development and Host Defense, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Glenn F Rall
Fox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
TRAINING PROGRAM IN CANCER RESEARCHT32CA009035 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CHERNOFF, JONATHAN · 1985 to 2020
$10.5M
Intra- and Inter-Neuronal Viral TraffickingR01NS060701 · NINDS · RESEARCH INST OF FOX CHASE CAN CTR · PI RALL, GLENN F · 2008 to 2012
$2.1M
Pathogenesis of Neurotropic RNA Virus InfectionsR01NS040500 · NINDS · RESEARCH INST OF FOX CHASE CAN CTR · PI RALL, GLENN F · 2002 to 2006
$1.6M
NCI NIH HHS P30-CA006927NCI NIH HHS T32 CA009035NINDS NIH HHS R01-NS060701NINDS NIH HHS R01-NS40500
6 · The paper itself

Abstract

While measles virus (MV) continues to have a significant impact on human health, causing 150,000-200,000 deaths worldwide each year, the number of fatalities that can be attributed to MV-triggered central nervous system (CNS) diseases are on the order of a few hundred individuals annually (World Health Organization 2009). Despite this modest impact, substantial effort has been expended to understand the basis of measles-triggered neuropathogenesis. What can be gained by studying such a rare condition? Simply stated, the wealth of studies in this field have revealed core principles that are relevant to multiple neurotropic pathogens, and that inform the broader field of viral pathogenesis. In recent years, the emergence of powerful in vitro systems, novel animal models, and reverse genetics has enabled insights into the basis of MV persistence, the complexity of MV interactions with neurons and the immune system, and the role of immune and CNS development in virus-triggered disease. In this review, we highlight some key advances, link relevant measles-based studies to the broader disciplines of neurovirology and viral pathogenesis, and propose future areas of study for the field of measles-mediated neurological disease.

Indexed as

Age FactorsAnimalsBiomedical ResearchBrainCentral Nervous System Viral DiseasesHumansMeaslesMiceNeuroimmunomodulation

Identifiers

PMID20419352
OpenAlexW1990736754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.