ArticleJournal of fluorescence2010
Simultaneous determination of xanthopterin and isoxanthopterin in human urine by synchronous fluorescence spectroscopy.
Article in Journal of fluorescence, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Characterization and Diagnosis of Liver Cirrhosis and Hepatocellular Carcinoma by Native Fluorescence Spectroscopy of Human Urine Coupled with Multivariate Statistical and Chemometric Methods.Cell biochemistry and biophysics · 2026Article
- Identifying Biomarkers for Chronic Obstructive Pulmonary Disease in the Salivary Metabolome.International journal of chronic obstructive pulmonary disease · 2026Article
- Pterin Profiling in Serum, Dried Blood Spot, and Urine Samples Using LC-MS/MS in Patients with Inherited Hyperphenylalaninemia.Molecular syndromology · 2024Article
- Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Synchronous luminescence spectroscopic characterization of urine of normal subjects and cancer patients.Journal of fluorescence · 2014Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
A simple, rapid, sensitive and selective method for simultaneously determining xanthopterin and isoxanthopterin content in human urine has been developed using synchronous fluorescence spectroscopy based on their intrinsic fluorescence. The synchronous fluorescence spectra were obtained with Δλ = 65 nm in a pH 8.5 KH(2)PO(4)-NaOH buffer solution. The detected wavelengths of quantitative analysis were set at 410 nm for xanthopterin and 325 nm for isoxanthopterin, respectively. Pretreatment of urine samples only was filtrated through a 0.45 μm membrane filter, which was free from the tedious separation procedures. Under optimized conditions, the limits of detection (LOD) were 0.94 ng/mL for xanthopterin and 0.48 ng/mL for isoxanthopterin. The recoveries ranged from 88.0% to 103.8 % for healthy and cancer urine samples, with coefficient of variation between 2.09% and 7.06%. The proposed method has been successfully applied to the simultaneous analysis for xanthopterin and isoxanthopterin in human urine. The results showed that the average level of isoxanthopterin was significantly elevated in urine excreted by stomach cancer patients (P < 0.01), while no significant change of xanthopterin level was found between stomach cancer patients and healthy individuals. This potentially indicates that an increase in amounts of isoxanthopterin can be associated with the presence of stomach cancer.
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