ReviewEuropean journal of applied physiology2010
Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres.
Review in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Corticospinal and spinal adaptations following lower limb motor skill training: a meta-analysis with best evidence synthesis.Experimental brain research · 2023Pooled it
- Acute Effects of Aerobic Exercise on Muscle Strength and Power in Trained Male Individuals: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Acute pre-exercise oral intake of cacao polyphenols attenuates central fatigue development during sustained low-intensity ankle dorsiflexion exercise in healthy young male adults.Physiological reports · 2026Trial
- Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.European journal of applied physiology · 2018Trial
- Low level laser therapy associated with a strength training program on muscle performance in elderly women: a randomized double blind control study.Lasers in medical science · 2016Trial
- Effects of photobiomodulation on the fatigue level in elderly women: an isokinetic dynamometry evaluation.Lasers in medical science · 2016Trial
- Effect of the Fatigue Induced by a 110-km Ultramarathon on Tibial Impact Acceleration and Lower Leg Kinematics.PloS one · 2016Trial
- Effects of extreme-duration heavy load carriage on neuromuscular function and locomotion: a military-based study.PloS one · 2012Trial
- The slow component of the [Formula: see text] response is associated with the increase in glycolytic contribution.European journal of applied physiology · 2026Article
- Reliability of M-wave amplitude measurement from paired stimulations across different muscle groups before and after submaximal contraction to failure.European journal of applied physiology · 2026Article
- Evaluation for the Efficacy of Exon-Skipping Therapy Using In Vivo Assessment of Skeletal Muscle Function and Fragility.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Effects of the modified field test on exercise-induced peripheral fatigue in non-elite badminton players.Frontiers in physiology · 2026Article
- Tamoxifen treatment fails to improve muscle dysfunction in a model of recessive RYR1-linked centronuclear myopathy.Disease models & mechanisms · 2025Article
- Divergent Effects of Calcium Channel Modulators on H-Reflex Excitability in Fatigued Rat Muscle.International journal of molecular sciences · 2025Article
- Effect of dry needling on quadriceps muscles fatigue in taekwondo players: A protocol for a triple-blinded randomized controlled trial.Contemporary clinical trials communications · 2025Article
- Fatigue Resistance and Mitochondrial Adaptations to Isometric Interval Training in Dystrophin-Deficient Muscle: Role of Contractile Load.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Materials and Structures Inspired by Human Heel Pads for Advanced Biomechanical Function.Biomimetics (Basel, Switzerland) · 2025Review
- Polyplex Nanomicelle-Mediated Pgc-1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Impact of sequence in concurrent training on physical activity, body composition, and fitness in obese young males: A 12-week randomized controlled trial.Journal of exercise science and fitness · 2025Article
- Alterations in the Neuromuscular Control Mechanism of the Legs During a Post-Fatigue Landing Make the Lower Limbs More Susceptible to Injury.Bioengineering (Basel, Switzerland) · 2025Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca(2+) handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise.
Indexed as
Identifiers
20419312What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.