ArticleCancer immunology, immunotherapy : CII2010
Distinct molecular mechanisms leading to deficient expression of ER-resident aminopeptidases in melanoma.
Article in Cancer immunology, immunotherapy : CII, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Deciphering genetic associations with blood pressure in peripheral blood mononuclear cells through single-cell transcriptomic profiling.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self.Cell reports · 2023Article
- The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy.Cancers · 2021Review
- Dysfunction of antigen processing and presentation by dendritic cells in cancer.Molecular immunology · 2019Review
- An allelic variant in the intergenic region between ERAP1 and ERAP2 correlates with an inverse expression of the two genes.Scientific reports · 2018Article
- The role of endoplasmic reticulum aminopeptidase 2 in modulating immune detection of choriocarcinoma.Biology of reproduction · 2018Article
- Endoplasmic Reticulum Aminopeptidase 2, a common immunological link to adverse pregnancy outcomes and cancer clearance?Placenta · 2017Review
- Article
- Antigen processing and immune regulation in the response to tumours.Immunology · 2017Review
- Exposure to Melan-A/MART-126-35 tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS).Scientific reports · 2016Article
- Molecular backgrounds of ERAP1 downregulation in cervical carcinoma.Analytical cellular pathology (Amsterdam) · 2015Article
- Genetic evolution of T-cell resistance in the course of melanoma progression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Modulating antigen processing for cancer immunotherapy.Oncoimmunology · 2014Article
- A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Frontiers in oncology · 2014Review
- Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes.International journal of clinical and experimental pathology · 2013Article
- Novel insights into the molecular mechanisms of HLA class I abnormalities.Cancer immunology, immunotherapy : CII · 2012Review
- Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.International journal of molecular sciences · 2012Review
- Association of ERAP1 Allelic Variants with Risk of Ankylosing Spondylitis.Acta naturae · 2010Article
- ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.OncoimmunologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune surveillance of tumour cells by CD8(+) cytotoxic T cells plays a key role in the establishment and control of an anti-tumour response. This process requires the generation of antigenic peptides, which are largely produced by the proteasome in combination with other proteases located in either the cytoplasm and/or the endoplasmic reticulum (ER). The ER-resident aminopeptidases ERAP1 and ERAP2 trim or even destroy HLA class I-binding peptides thereby shaping the peptide repertoire presented for T cell recognition. So far there exists limited information about the expression pattern of ERAP1 and/or ERAP2 in human tumours of distinct histotypes. Therefore, the expression profiles and modes of regulation of both aminopeptidases were determined in a large series of melanoma cell lines. A heterogeneous expression ranging from high to reduced or even total loss of ERAP1 and/or ERAP2 mRNA and/or protein expression was detected, which often could be induced/upregulated by interferon-gamma treatment. The observed altered ERAP1 and/or ERAP2 expression and activity levels were either mediated by sequence alterations affecting the promoter or enzymatic activities, leading to either transcriptional and/or post-transcriptional downregulation mechanisms or limited or excessive processing activities, which both might have an impact on the antigenic peptide repertoire presented on HLA class I molecules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.