ArticleJournal of molecular medicine (Berlin, Germany)2010
Penetration of the blood-brain barrier by Staphylococcus aureus: contribution of membrane-anchored lipoteichoic acid.
Article in Journal of molecular medicine (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 77 citations in OpenAlex.
- Article
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- A Water-Soluble Aggregation-Induced Emission Photosensitizer with Intrinsic Antibacterial Activity as an Antiplanktonic and Antibiofilm Therapeutic Agent.Journal of medicinal chemistry · 2025Article
- The endothelium at the interface between tissues andClinical microbiology reviews · 2025Review
- Glycosylation of oral bacteria in modulating adhesion and biofilm formation.Journal of oral microbiology · 2025Review
- Lipoteichoic acid biosynthesis bymBio · 2024Article
- Immunization with a peptide mimicking lipoteichoic acid induces memory B cells in BALB/c mice.BMC infectious diseases · 2024Article
- Mechanistic Studies andJournal of medicinal chemistry · 2022Article
- Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders.The European journal of neuroscience · 2022Review
- Investigation of many bacterial and viral infections circulating in pigeons showing nervous symptoms.Saudi journal of biological sciences · 2022Article
- Rapid Inhibitor Discovery by Exploiting Synthetic Lethality.Journal of the American Chemical Society · 2022Article
- The Lipoteichoic Acid-Related Proteins YqgS and LafA Contribute to the Resistance of Listeria monocytogenes to Nisin.Microbiology spectrum · 2022Article
- Neuroinflammation in neurodegenerationFrontiers in immunology · 2022Review
- Burr hole on polyetheretherketone cranioplasty for the management of chronic subdural hematoma: A case report.Surgical neurology international · 2022Article
- Infective Endocarditis from Furuncle with Meningitis Complication Caused by Methicillin-resistant Staphylococcus aureus.Internal medicine (Tokyo, Japan) · 2021Article
- Antimicrobial responses of peripheral and central nervous system glia against Staphylococcus aureus.Scientific reports · 2021Article
- Lipoteichoic acid polymer length is determined by competition between free starter units.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The length of lipoteichoic acid polymers controlsJournal of bacteriology · 2020Article
- Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer's disease mice.Journal of neuroinflammation · 2020Article
- Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus.PLoS pathogens · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Staphylococcus aureus is one of the most prevalent organisms responsible for nosocomial infections, and cases of community-acquired S. aureus infection have continued to increase despite widespread preventative measures. Pathologies attributed to S. aureus infection are diverse; ranging from dermal lesions to bacteremia, abscesses, and endocarditis. Reported cases of S. aureus-associated meningitis and brain abscesses have also increased in recent years, however, the precise mechanism whereby S. aureus leave the bloodstream and gain access to the central nervous system (CNS) are not known. Here we demonstrate for the first time that S. aureus efficiently adheres to and invades human brain microvascular endothelial cells (hBMEC), the single-cell layer which constitutes the blood-brain barrier (BBB). The addition of cytochalasin D, an actin microfilament aggregation inhibitor, strongly reduced bacterial invasion, suggesting an active hBMEC process is required for efficient staphylococcal uptake. Furthermore, mice injected with S. aureus exhibited significant levels of brain bacterial counts and histopathologic evidence of meningeal inflammation and brain abscess formation, indicating that S. aureus was able to breech the BBB in an experimental model of hematogenous meningitis. We found that a YpfP-deficient mutant, defective in lipoteichoic acid (LTA) membrane anchoring, exhibited a decreased ability to invade hBMEC and correlated to a reduced risk for the development of meningitis in vivo. Our results demonstrate that LTA-mediated penetration of the BBB may be a primary step in the pathogenesis of staphylococcal CNS disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.