ArticleNature immunology2010
Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.
Article in Nature immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 110 citations in OpenAlex.
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- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- How type-2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell-T cell communication?Allergy · 2025Review
- Of Tingible Bodies and Starry Skies: Control of Normal and Malignant Tissues Through Apoptotic Cell-Dependent Communication (ACDC).Advances in experimental medicine and biology · 2025Review
- The amalgam of naive CD4Immunity · 2024Article
- Site-specific regulation of Th2 differentiation within lymph node microenvironments.The Journal of experimental medicine · 2024Article
- Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.The Journal of experimental medicine · 2024Article
- Distinct spatiotemporal dynamics of CD8Cancer cell · 2024Article
- The spread of interferon-γ in melanomas is highly spatially confined, driving nongenetic variability in tumor cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering ACell reports · 2022Article
- Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism.Immunity · 2022Article
- Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response.Mucosal immunology · 2022Article
- Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation.Immunity · 2021Article
- Quorum sensing governs collective dendritic cell activation in vivo.The EMBO journal · 2021Article
- Modulation of the tumor micro-environment by CD8Current opinion in immunology · 2021Review
- Quorum sensing via dynamic cytokine signaling comprehensively explains divergent patterns of effector choice among helper T cells.PLoS computational biology · 2020Article
- Expression Efficiency of MultipleImmunoHorizons · 2020Article
- Modes of Communication between T Cells and Relevance for Immune Responses.International journal of molecular sciences · 2020Review
- Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.Nature cancer · 2020Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cytokines are soluble proteins that regulate immune responses. The present paradigm is that cytokine production in lymphoid tissues is tightly localized and signaling occurs between conjugate cells. Here we assess cytokine signaling during infection by measuring in vivo phosphorylation of intracellular signal transducer and activator of transcription (STAT) proteins. We show that interferon-gamma (IFN-gamma) and interleukin 4 (IL-4) signaled to the majority of lymphocytes throughout the reactive lymph node and that IL-4 conditioning of naive, bystander cells was sufficient to override opposing T helper type 1 (T(H)1) polarization. Our results demonstrate that despite localized production, cytokines can permeate a lymph node and modify the majority of cells therein. Cytokine conditioning of bystander cells could provide a mechanism by which chronic worm infections subvert the host response to subsequent infections or vaccination attempts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.