ArticleNature methods2010
Targeted gene deletions in C. elegans using transposon excision.
Article in Nature methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Canonical and noncanonical Hippo signaling in C. elegans.Genetics · 2026Article
- Article
- Formation of artificial chromosomes in Caenorhabditis elegans and analyses of their segregation in mitosis, DNA sequence composition and holocentromere organization.Nucleic acids research · 2021Article
- Visualization and Quantification of Transposon Activity inG3 (Bethesda, Md.) · 2019Article
- TheGenetics · 2019Review
- Using genetics to understand biology.Heredity · 2019Review
- Genome-Wide Determination of Gene Essentiality by Transposon Insertion Sequencing in Yeast Pichia pastoris.Scientific reports · 2018Article
- Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.PLoS biology · 2017Article
- Reliable CRISPR/Cas9 Genome Engineering inG3 (Bethesda, Md.) · 2017Article
- An SMC-like protein binds and regulates Caenorhabditis elegans condensins.PLoS genetics · 2017Article
- Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing.G3 (Bethesda, Md.) · 2016Article
- Article
- Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Molecular biology of the cell · 2016Article
- Review
- Targeted genome engineering inCell & bioscience · 2016Review
- Article
- Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes.Genetics · 2015Article
- Article
- The application of CRISPR-Cas9 genome editing in Caenorhabditis elegans.Journal of genetics and genomics = Yi chuan xue bao · 2015Review
- C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types.Development (Cambridge, England) · 2015Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
We developed a method, MosDEL, to generate targeted knockouts of genes in Caenorhabditis elegans by injection. We generated a double-strand break by mobilizing a Mos1 transposon adjacent to the region to be deleted; the double-stranded break is repaired using injected DNA as a template. Repair can delete up to 25 kb of DNA and simultaneously insert a positive selection marker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.