ArticleThe Pediatric infectious disease journal2010
Invasive bacterial infections in neonates and young infants born outside hospital admitted to a rural hospital in Kenya.
Article in The Pediatric infectious disease journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 6 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Sex differences in bacterial meningitis and associations with socioeconomic indicators: a systematic review and meta-analysis with metaregression.BMJ global health · 2025Pooled it
- Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Contemporary Trends in Global Mortality of Sepsis Among Young Infants Less Than 90 Days: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis.International journal of public health · 2020Pooled it
- Antimicrobial resistance among children in sub-Saharan Africa.The Lancet. Infectious diseases · 2018Pooled it
- Burden of bacterial resistance among neonatal infections in low income countries: how convincing is the epidemiological evidence?BMC infectious diseases · 2015Pooled it
- Age-Specific Concentrations and Seroprevalence of Antibodies Against Salmonella Enteritidis (O:9) and Salmonella Typhimurium (O:4,5) Across 3 Sites in Kenya.The Journal of infectious diseases · 2026Article
- Development of two multiplex PCR assays for rapid detection of eleven Gram-negative bacteria in children with septicemia.Tropical medicine and health · 2024Article
- Antimicrobial Properties of Colostrum and Milk.Antibiotics (Basel, Switzerland) · 2024Review
- The epidemiology of fecal carriage of nontyphoidal Salmonella among healthy children and adults in three sites in Kenya.PLoS neglected tropical diseases · 2023Article
- Invasive bacterial disease in young infants in rural Gambia: Population-based surveillance.Journal of global health · 2023Article
- Three developed spectrophotometric methods for determination of a mixture of ofloxacin and ornidazole; application of greenness assessment tools.BMC chemistry · 2023Article
- Using Machine Learning to Predict Invasive Bacterial Infections in Young Febrile Infants Visiting the Emergency Department.Journal of clinical medicine · 2021Article
- Can breastfeeding protect against antimicrobial resistance?BMC medicine · 2020Article
- Article
- Reagent Strips as an Aid to Diagnosis of Neonatal Meningitis in a Resource-limited Setting.Journal of tropical pediatrics · 2019Article
- Competing risk survival analysis of time to in-hospital death or discharge in a large urban neonatal unit in Kenya.Wellcome open research · 2019Article
- Should First-line Empiric Treatment Strategies for Neonates Cover Coagulase-negative Staphylococcal Infections in Kenya?The Pediatric infectious disease journal · 2017Article
- Etiology of bacterial meningitis: a cross-sectional study among patients admitted in a semi-urban hospital in Nairobi, Kenya.The Pan African medical journal · 2017Article
- Codevelopment of Microbiota and Innate Immunity and the Risk for Group B Streptococcal Disease.Frontiers in immunology · 2017Review
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5 authors.
Funding
Abstract
backgroundBacterial sepsis is thought to be a major cause of young infant deaths in low-income countries, but there are few precise estimates of its burden or causes. We studied invasive bacterial infections (IBIs) in young infants, born at home or in first-level health units ("outborn") who were admitted to a Kenyan rural district hospital during an 8-year period.
methodsClinical and microbiologic data, from admission blood cultures and cerebrospinal fluid cultures on all outborn infants aged less than 60 days admitted from 2001 to 2009, were examined to determine etiology of IBI and antimicrobial susceptibilities.
resultsOf the 4467 outborn young infants admitted, 748 (17%) died. Five hundred five (11%) had IBI (10% bacteremia and 3% bacterial meningitis), with a case fatality of 33%. The commonest organisms were Klebsiella spp., Staphylococcus aureus, Streptococcus pneumoniae, Group B Streptococcus, Acinetobacter spp., Escherichia coli, and Group A Streptococcus. Notably, some blood culture isolates were seen in outborn neonates in the first week of life but not in inborns: Salmonella, Aeromonas, and Vibrio spp. Eighty-one percent of isolates were susceptible to penicillin and/or gentamicin and 84% to ampicillin and/or gentamicin. There was a trend to increasing in vitro antimicrobial resistance to these combinations from 2008 but without a worse outcome.
conclusionsIBI is common in outborn young infants admitted to rural African hospitals with a high mortality. Presumptive antimicrobial use is justified for all young infants admitted to the hospital.
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